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Tclin
FXYD2
Sodium/potassium-transporting ATPase subunit gamma

Protein Summary
Description
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260287
  • ENSP00000260287
  • ENSG00000137731
  • ENST00000292079
  • ENSP00000292079
  • ENST00000528014
  • ENSP00000432430
  • ENST00000532119
  • ENSP00000436414

Symbol
  • ATP1C
  • ATP1G1
  • HOMG2
  • ATP1G1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
cellular component
0.63
tissue
0.62
transcription factor
0.62
cell type or tissue
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.95   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 82   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.95   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
2
2
0
4.3
71.8
refractive error measurement
2
2
1
7.5
71.8
age at onset
1
1
0
7.5
59.9
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Myopia
0
4.3
71.8
refractive error measurement
1
7.5
71.8
age at onset
0
7.5
59.9
1
30.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1195260
11936
Rat
RGD:2173
29639
Dog
FXYD domain containing ion transport regulator 2
VGNC:41020
608594
Horse
FXYD domain containing ion transport regulator 2 [Source:HGNC Symbol;Acc:HGNC:4026]
Cow
FXYD domain containing ion transport regulator 2
VGNC:29157
281773
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
FXYD domain containing ion transport regulator 2
Horse
FXYD domain containing ion transport regulator 2 [Source:HGNC Symbol;Acc:HGNC:4026]
Cow
FXYD domain containing ion transport regulator 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P54710-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Protein-Protein Interactions (68)
1 – 10 of 68
ATP1A1
Tclin
Family:  Transporter
Novelty:  0.01078788
Score:  0.995
Data Source:  STRINGDB
ATP1B1
Tclin
Family:  Transporter
Novelty:  0.025056
Score:  0.989
Data Source:  STRINGDB
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
Score:  0.98
Data Source:  STRINGDB
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
Score:  0.975
Data Source:  STRINGDB
ATP1A3
Tclin
Family:  Transporter
Novelty:  0.00485594
Score:  0.97
Data Source:  STRINGDB
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
Score:  0.968
Data Source:  STRINGDB
ATP1B2
Tclin
Family:  Transporter
Novelty:  0.02641193
Score:  0.967
Data Source:  STRINGDB
ATP1B4
Tdark
Family:  Transporter
Novelty:  0.08212894
Score:  0.954
Data Source:  STRINGDB
UGT1A6
Tbio
Family:  Enzyme
Novelty:  0.00146917
Score:  0.904
Data Source:  STRINGDB
HMOX1
Tchem
Family:  Enzyme
Novelty:  0.00013981
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  50.95

PubMed score by year
PubTator Score  30.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer