Tclin FXYD2 Sodium/potassium-transporting ATPase subunit gamma

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Sodium/potassium-transporting Atpase Subunit Gamma

Protein / Transporter / Cation Transporter / Sodium/potassium-transporting Atpase Subunit Gamma

Protein / Enzyme Modulator / Sodium/potassium-transporting Atpase Subunit Gamma

DTO Classes

Protein / Transporter / P-type Atpases / Na+/k+-atpases / Sodium/potassium-transporting Atpase Subunit Gamma

Protein Summary

Description

May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• P54710
• Q15332
• Q53YC1
• Q9GZP3
• Q9GZQ7
• Na(+)/K(+) ATPase subunit gamma

Gene Name

• FXYD2

Ensembl ID

• ENST00000260287
• ENSP00000260287
• ENSG00000137731
• ENST00000292079
• ENSP00000292079
• ENST00000528014
• ENSP00000432430
• ENST00000532119
• ENSP00000436414

Symbol

• ATP1C
• ATP1G1
• HOMG2
• ATP1G1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
cellular component	0.63
tissue	0.62
transcription factor	0.62
cell type or tissue	0.56

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.95   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 82   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.95   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 82   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3

Approved Drugs (3)

Explore Approved Drugs

1 – 3 of 3

digoxin

FXYD2Tclin Enzyme

INHIBITOR IC50 : 6.4

acetyldigitoxin

FXYD2Tclin Enzyme

INHIBITOR :

deslanoside

FXYD2Tclin Enzyme

INHIBITOR :

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Myopia	HP_0000545	2	2	0	4.3	71.8
refractive error measurement	EFO_0007814	2	2	1	7.5	71.8
age at onset	EFO_0004847	1	1	0	7.5	59.9
type II diabetes mellitus	EFO_0001360	1	1	1		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Myopia	HP_0000545	0	4.3	71.8
refractive error measurement	EFO_0007814	1	7.5	71.8
age at onset	EFO_0004847	0	7.5	59.9
type II diabetes mellitus	EFO_0001360	1		30.2

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Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	FXYD domain-containing ion transport regulator 2	MGI:1195260	11936
Rat	FXYD domain-containing ion transport regulator 2	RGD:2173	29639
Dog	FXYD domain containing ion transport regulator 2	VGNC:41020	608594
Horse	FXYD domain containing ion transport regulator 2 [Source:HGNC Symbol;Acc:HGNC:4026]
Cow	FXYD domain containing ion transport regulator 2	VGNC:29157	281773

Species	Name	OMA	EggNOG	Inparanoid
Mouse	FXYD domain-containing ion transport regulator 2
Rat	FXYD domain-containing ion transport regulator 2
Dog	FXYD domain containing ion transport regulator 2
Horse	FXYD domain containing ion transport regulator 2 [Source:HGNC Symbol;Acc:HGNC:4026]
Cow	FXYD domain containing ion transport regulator 2

Protein Structure (1 Structure, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P54710-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (23)

Reactome (6)

KEGG (16)

WikiPathways (1)

Cardiac conduction (R-HSA-5576891)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cardiac conduction	137 targets	R-HSA-5576891
Reactome	Ion channel transport	179 targets	R-HSA-983712
Reactome	Ion homeostasis	52 targets	R-HSA-5578775
Reactome	Ion transport by P-type ATPases	55 targets	R-HSA-936837
Reactome	Muscle contraction	202 targets	R-HSA-397014

Name	Explore in Pharos	Explore in Source
Cardiac conduction	137 targets	R-HSA-5576891
Ion channel transport	179 targets	R-HSA-983712
Ion homeostasis	52 targets	R-HSA-5578775
Ion transport by P-type ATPases	55 targets	R-HSA-936837
Muscle contraction	202 targets	R-HSA-397014

Gene Ontology Terms (11)

Functions (4)

Components (3)

Processes (4)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
sodium channel regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sodium:potassium-exchanging ATPase activity	Traceable Author Statement (TAS)	ProtInc
transporter activity	Traceable Author Statement (TAS)	ProtInc
ion channel activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

ATP1A1

Tclin

Family:  Transporter

Novelty:  0.01078788

Score:  0.995

Data Source:  STRINGDB

ATP1B1

Tclin

Family:  Transporter

Novelty:  0.025056

Score:  0.989

Data Source:  STRINGDB

ATP1A4

Tclin

Family:  Transporter

Novelty:  0.01011201

Score:  0.98

Data Source:  STRINGDB

ATP1B3

Tclin

Family:  Transporter

Novelty:  0.06773518

Score:  0.975

Data Source:  STRINGDB

ATP1A3

Tclin

Family:  Transporter

Novelty:  0.00485594

Score:  0.97

Data Source:  STRINGDB

ATP1A2

Tclin

Family:  Transporter

Novelty:  0.00606202

Score:  0.968

Data Source:  STRINGDB

ATP1B2

Tclin

Family:  Transporter

Novelty:  0.02641193

Score:  0.967

Data Source:  STRINGDB

ATP1B4

Tdark

Family:  Transporter

Novelty:  0.08212894

Score:  0.954

Data Source:  STRINGDB

UGT1A6

Tbio

Family:  Enzyme

Novelty:  0.00146917

Score:  0.904

Data Source:  STRINGDB

HMOX1

Tchem

Family:  Enzyme

Novelty:  0.00013981

Score:  0.9

Data Source:  STRINGDB

Publication Statistics

PubMed Score  50.95

PubMed score by year

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PubTator Score  30.39

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Disease mutation
Ion transport
Membrane
Potassium
Potassium transport
Primary hypomagnesemia
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at onset
Myopia
refractive error measurement
type II diabetes mellitus