FXYD2
Sodium/potassium-transporting ATPase subunit gamma
Protein Summary
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011]
- ENST00000260287
- ENSP00000260287
- ENSG00000137731
- ENST00000292079
- ENSP00000292079
- ENST00000528014
- ENSP00000432430
- ENST00000532119
- ENSP00000436414
- ATP1C
- ATP1G1
- HOMG2
- ATP1G1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.99 | ||
cellular component | 0.63 | ||
tissue | 0.62 | ||
transcription factor | 0.62 | ||
cell type or tissue | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.95 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 82 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 50.95 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 82 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (0)
Protein-Protein Interactions (68)
Nearest Tclin Targets
Pathways (23)
Reactome (6)
KEGG (16)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cardiac conduction | ||||
Reactome | Ion channel transport | ||||
Reactome | Ion homeostasis | ||||
Reactome | Ion transport by P-type ATPases | ||||
Reactome | Muscle contraction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cardiac conduction | ||||
Ion channel transport | ||||
Ion homeostasis | ||||
Ion transport by P-type ATPases | ||||
Muscle contraction | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (4)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
Myopia | 2 | 2 | 0 | 4.3 | 71.8 | ||||
refractive error measurement | 2 | 2 | 1 | 7.5 | 71.8 | ||||
age at onset | 1 | 1 | 0 | 7.5 | 59.9 | ||||
1 | 1 | 1 | 30.2 | ||||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
Myopia | 0 | 4.3 | 71.8 | ||||
refractive error measurement | 1 | 7.5 | 71.8 | ||||
age at onset | 0 | 7.5 | 59.9 | ||||
1 | 30.2 | ||||||
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IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1195260 | 11936 | ||||||
Rat | RGD:2173 | 29639 | ||||||
Dog | FXYD domain containing ion transport regulator 2 | VGNC:41020 | 608594 | |||||
Horse | FXYD domain containing ion transport regulator 2 [Source:HGNC Symbol;Acc:HGNC:4026] | |||||||
Cow | FXYD domain containing ion transport regulator 2 | VGNC:29157 | 281773 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | FXYD domain containing ion transport regulator 2 | |||||
Horse | FXYD domain containing ion transport regulator 2 [Source:HGNC Symbol;Acc:HGNC:4026] | |||||
Cow | FXYD domain containing ion transport regulator 2 | |||||
Publication Statistics
PubMed Score 50.95
PubMed score by year
PubTator Score 30.39
PubTator score by year
Related Publications
Text Mined References (35)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
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