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Tchem
BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

Protein Summary
Description
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261192
  • ENSP00000261192
  • ENSG00000060982
  • ENST00000342945
  • ENSP00000339805
  • ENST00000538118
  • ENSP00000440817
  • ENST00000539282
  • ENSP00000443459
  • ENST00000539780
  • ENSP00000440827

Symbol
  • BCT1
  • ECA39
  • BCT1
  • PP18
  • BCATC
  • ECA39
  • MECA39
  • PNAS121
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
PubMedID
0.97
transcription factor perturbation
0.97
disease perturbation
0.87
transcription factor
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.83   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 170.83   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (29)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (99)
1 – 10 of 99
MORN5
Tdark
Novelty: 1.51123721
p_int: 0.997773847
p_ni: 0.002226153
Score: 0.248
Data Source: BioPlex,STRINGDB
GFOD1
Tdark
Family: Enzyme
Novelty: 0.35031766
p_int: 0.996004112
p_ni: 0.003995888
Score: 0.191
Data Source: BioPlex,STRINGDB
TRIP12
Tbio
Family: Enzyme
Novelty: 0.03433452
p_int: 0.975142692
p_ni: 0.017851476
p_wrong: 0.007005833
Score: 0.212
Data Source: BioPlex,STRINGDB
ARNT
Tbio
Family: TF
Novelty: 0.00183071
p_int: 0.950157583
p_ni: 0.049841461
p_wrong: 9.55e-7
Score: 0.155
Data Source: BioPlex,STRINGDB
ATXN2
Tbio
Novelty: 0.00373116
p_int: 0.940060676
p_ni: 0.059918081
p_wrong: 0.000021243
Score: 0.156
Data Source: BioPlex,STRINGDB
PPP2R5D
Tbio
Family: Enzyme
Novelty: 0.03990599
p_int: 0.927085523
p_ni: 0.07289786
p_wrong: 0.000016618
Score: 0.157
Data Source: BioPlex,STRINGDB
YEATS2
Tbio
Novelty: 0.17584498
p_int: 0.926516888
p_ni: 0.073483112
Score: 0.151
Data Source: BioPlex,STRINGDB
RAB3GAP1
Tbio
Family: Enzyme
Novelty: 0.0286836
p_int: 0.92007706
p_ni: 0.07991784
p_wrong: 0.0000051
Data Source: BioPlex
CCDC120
Tbio
Novelty: 0.48574876
p_int: 0.915709983
p_ni: 0.084290016
p_wrong: 1e-9
Data Source: BioPlex
PRXL2B
Tdark
Family: Enzyme
Novelty: 0.34235664
p_int: 0.915081602
p_ni: 0.084918397
p_wrong: 1e-9
Score: 0.188
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  170.83

PubMed score by year
PubTator Score  51.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer