Tchem BCAT1 Branched-chain-amino-acid aminotransferase, cytosolic

Protein Summary

Description

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P54687
• B3KY27
• B7Z2M5
• B7Z5L0
• F5H5E4
• Q68DQ7
• Q96MY9
• BCAT(c)

Gene Name

• BCAT1

Ensembl ID

• ENST00000261192
• ENSP00000261192
• ENSG00000060982
• ENST00000342945
• ENSP00000339805
• ENST00000538118
• ENSP00000440817
• ENST00000539282
• ENSP00000443459
• ENST00000539780
• ENSP00000440827

Symbol

• BCT1
• ECA39
• BCT1
• PP18
• BCATC
• ECA39
• MECA39
• PNAS121

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
PubMedID	0.97
transcription factor perturbation	0.97
disease perturbation	0.87
transcription factor	0.87

Protein Classes

PANTHER Classes

Protein / Transferase / Transaminase / Branched-chain-amino-acid Aminotransferase, Cytosolic

DTO Classes

Protein / Enzyme / Transferase / Transaminase / Branched-chain-amino-acid Aminotransferase, Cytosolic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.74   (req: < 5)

Gene RIFs: 50   (req: <= 3)

Antibodies: 331   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 240.74   (req: >= 5)

Gene RIFs: 50   (req: > 3)

Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0