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Tbio
HSPA2
Heat shock-related 70 kDa protein 2

Protein Summary
Description
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and rel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247207
  • ENSP00000247207
  • ENSG00000126803
  • ENST00000394709
  • ENSP00000378199

Symbol
  • HSP70-2
  • HSP70-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
gene perturbation
0.96
PubMedID
0.87
molecular function
0.86
histone modification site profile
0.85


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.31   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 241   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.31   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 241   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:96243
15512
Rat
RGD:620664
60460
Dog
heat shock protein family A (Hsp70) member 2
VGNC:50533
480355
Platypus
heat shock protein family A (Hsp70) member 2
100079663
Anole lizard
heat shock protein family A (Hsp70) member 2
100551584
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
heat shock protein family A (Hsp70) member 2
Platypus
heat shock protein family A (Hsp70) member 2
Anole lizard
heat shock protein family A (Hsp70) member 2
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (35)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cell Cycle
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cell Cycle
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Gene Ontology Terms (42)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (280)
1 – 10 of 280
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.991033419
p_ni: 0.008966581
Score: 0.981
Data Source: BioPlex,STRINGDB
PRODH
Tbio
Family: Enzyme
Novelty: 0.00315806
p_int: 0.943750447
p_ni: 0.056249553
Score: 0.572
Data Source: BioPlex,STRINGDB
ILK
Tchem
Family: Kinase
Novelty: 0.00147344
p_int: 0.940150175
p_ni: 0.059849825
Score: 0.7
Data Source: BioPlex,STRINGDB
KLHL34
Tdark
Novelty: 2.18471039
p_int: 0.937995065
p_ni: 0.062004935
Score: 0.531
Data Source: BioPlex,STRINGDB
SOHLH1
Tbio
Family: TF
Novelty: 0.04218087
p_int: 0.935227733
p_ni: 0.064772267
Data Source: BioPlex
HSPBP1
Tbio
Novelty: 0.01176285
p_int: 0.925514619
p_ni: 0.074485381
Score: 0.709
Data Source: BioPlex,STRINGDB
ABHD15
Tdark
Family: Enzyme
Novelty: 1.53507944
p_int: 0.919856708
p_ni: 0.080143292
Score: 0.67
Data Source: BioPlex,STRINGDB
ELP4
Tbio
Novelty: 0.03734233
p_int: 0.904564259
p_ni: 0.095435742
Data Source: BioPlex
TRMU
Tbio
Family: Enzyme
Novelty: 0.01615197
p_int: 0.899277377
p_ni: 0.100722623
Score: 0.158
Data Source: BioPlex,STRINGDB
NOXO1
Tbio
Family: Enzyme
Novelty: 0.02648748
p_int: 0.882140655
p_ni: 0.117859346
Data Source: BioPlex
Publication Statistics
PubMed Score  60.31

PubMed score by year
PubTator Score  101.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer