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Tchem
PRKAG1
5'-AMP-activated protein kinase subunit gamma-1

Protein Summary
Description
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating alread ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316299
  • ENSP00000323867
  • ENSG00000181929
  • ENST00000548065
  • ENSP00000447433
  • ENST00000552212
  • ENSP00000448972

Symbol
  • AMPKG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
1
co-expressed gene
0.99
transcription factor binding site profile
0.87
transcription factor
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.48   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
PF-3758309
Rendered image for PF-3758309
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
16
99.2
cognitive function measurement
3
2
3
86.2
intelligence
6
6
4
6.1
83.3
bone density
3
2
4
75.2
self reported educational attainment
4
1
3
6.1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
16
99.2
cognitive function measurement
3
86.2
intelligence
4
6.1
83.3
bone density
4
75.2
self reported educational attainment
3
6.1
74.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated non-catalytic subunit gamma 1
VGNC:8504
451872
Macaque
protein kinase AMP-activated non-catalytic subunit gamma 1
709298
Mouse
MGI:108411
19082
Dog
protein kinase AMP-activated non-catalytic subunit gamma 1
VGNC:44972
486559
Horse
protein kinase AMP-activated non-catalytic subunit gamma 1
VGNC:21839
100034096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated non-catalytic subunit gamma 1
Macaque
protein kinase AMP-activated non-catalytic subunit gamma 1
Mouse
Dog
protein kinase AMP-activated non-catalytic subunit gamma 1
Horse
protein kinase AMP-activated non-catalytic subunit gamma 1
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P54619-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (63)
Activation of AMPK downstream of NMDARs (R-HSA-9619483)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Autophagy
Cellular responses to external stimuli
Gene Ontology Terms (22)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
BHF-UCL
Protein-Protein Interactions (195)
1 – 10 of 195
PRKAB1
Tchem
Family:  Kinase
Novelty:  0.01610606
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAB2
Tchem
Family:  Enzyme
Novelty:  0.02815065
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAA2
Tchem
Family:  Kinase
Novelty:  0.01795523
p_int:  0.999999859
p_ni:  1.41e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
p_int:  0.999999824
p_ni:  1.76e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
STIM2
Tbio
Novelty:  0.00446493
p_int:  0.998806739
p_ni:  0.001193236
p_wrong:  2.5e-8
Score:  0.817
Data Source:  BioPlex,STRINGDB
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.994880518
p_ni:  0.00511948
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
PHKG2
Tchem
Family:  Kinase
Novelty:  0.064884
p_int:  0.967606278
p_ni:  0.032393722
Score:  0.844
Data Source:  BioPlex,STRINGDB
CUTA
Tbio
Novelty:  0.01771609
p_int:  0.953873813
p_ni:  0.046126187
Score:  0.765
Data Source:  BioPlex,STRINGDB
MFSD4B
Tdark
Novelty:  0.03380333
p_int:  0.937730028
p_ni:  0.017049091
p_wrong:  0.045220881
Score:  0.193
Data Source:  BioPlex,STRINGDB
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.931639867
p_ni:  0.068360065
p_wrong:  6.8e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.48

PubMed score by year
PubTator Score  5.53

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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