Tchem YARS Tyrosine--tRNA ligase, cytoplasmic

Protein Summary

Description

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P54577
• B3KWK4
• D3DPQ4
• O43276
• Q53EN1

Gene Name

• YARS

Ensembl ID

• ENST00000373477
• ENSP00000362576
• ENSG00000134684

Symbol

• YRS
• YTS
• TYRRS
• CMTDIC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
kinase perturbation	0.98
transcription factor binding site profile	0.94
co-expressed gene	0.87
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Tyrosine--trna Ligase, Cytoplasmic

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Tyrosine--trna Ligase, Cytoplasmic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.22   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 242   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.22   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0