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Tbio
OAZ1
Ornithine decarboxylase antizyme 1

Protein Summary
Description
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147). The protein encoded by this gene belongs to the ornithine decarboxylase antizym ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000602676
  • ENSP00000473381
  • ENSG00000104904

Symbol
  • OAZ
  • AZ1
  • AZI
  • OAZ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
virus perturbation
0.88
transcription factor perturbation
0.84
transcription factor binding site profile
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.21   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.21   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
AZIN2
Tbio
Family:  Enzyme
Novelty:  0.00750311
p_int:  1
Score:  0.87
Data Source:  BioPlex,STRINGDB
AZIN1
Tbio
Family:  Enzyme
Novelty:  0.03017595
p_int:  0.999999026
p_ni:  9.4e-7
p_wrong:  3.4e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
ODC1
Tclin
Family:  Enzyme
Novelty:  0.00037968
Score:  0.999
Data Source:  Reactome,STRINGDB
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
Score:  0.965
Data Source:  STRINGDB
AURKAIP1
Tchem
Family:  Enzyme
Novelty:  0.19241693
Score:  0.955
Data Source:  STRINGDB
PSMA3
Tbio
Family:  Enzyme
Novelty:  0.03106507
Score:  0.955
Data Source:  STRINGDB
PSMB4
Tbio
Family:  Enzyme
Novelty:  0.0376233
Score:  0.953
Data Source:  STRINGDB
OAZ3
Tbio
Family:  Enzyme
Novelty:  0.02374168
Score:  0.945
Data Source:  STRINGDB
OAZ2
Tbio
Family:  Enzyme
Novelty:  0.1687351
Score:  0.94
Data Source:  STRINGDB
PSMB6
Tbio
Family:  Enzyme
Novelty:  0.04738037
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of polyamines
Reactome
Regulation of ornithine decarboxylase (ODC)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Metabolism of polyamines
Regulation of ornithine decarboxylase (ODC)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
4
4
97.8
pulse pressure measurement
4
4
4
93.2
BMI-adjusted hip circumference
3
7
9
91
BMI-adjusted waist-hip ratio
5
5
7
90.4
heel bone mineral density
3
2
4
89.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
97.8
pulse pressure measurement
4
93.2
BMI-adjusted hip circumference
9
91
BMI-adjusted waist-hip ratio
7
90.4
heel bone mineral density
4
89.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ornithine decarboxylase antizyme 1
VGNC:2297
455569
Macaque
ornithine decarboxylase antizyme 1
721477
Mouse
MGI:109433
18245
Rat
RGD:3219
25502
Dog
ornithine decarboxylase antizyme 1
476749
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ornithine decarboxylase antizyme 1
Macaque
ornithine decarboxylase antizyme 1
Mouse
Rat
Dog
ornithine decarboxylase antizyme 1
Publication Statistics
PubMed Score 47.21
PubMed score by year
PubTator Score 42.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title