Tbio PNLIPRP1 Inactive pancreatic lipase-related protein 1

Protein Summary

Description

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

Uniprot Accession IDs

• P54315
• Q68D83
• Q68DR6
• Q8TAU2
• Q9BS82
• PL-RP1

Gene Name

• PNLIPRP1

Ensembl ID

• ENST00000358834
• ENSP00000351695
• ENSG00000187021
• ENST00000528052
• ENSP00000433933

Symbol

• PLRP1
• PLRP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
protein domain	0.92
gene perturbation	0.84
disease perturbation	0.49
kinase perturbation	0.48

Protein Classes

PANTHER Classes

Protein / Storage Protein / Inactive Pancreatic Lipase-related Protein 1

Protein / Hydrolase / Lipase / Inactive Pancreatic Lipase-related Protein 1

Protein / Hydrolase / Esterase / Inactive Pancreatic Lipase-related Protein 1

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Inactive Pancreatic Lipase-related Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.77   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 68   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.77   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (68)

Explore Interacting Targets

1 – 10 of 68

• See Interactions on String-DB

ITGA8

Tbio

Novelty:  0.0220023

p_int:  0.975402814

p_ni:  0.024153881

p_wrong:  0.000443305

Data Source:  BioPlex

CEMIP2

Tbio

Novelty:  0.04698236

p_int:  0.963663778

p_ni:  0.036334561

p_wrong:  0.000001662

Score:  0.188

Data Source:  BioPlex,STRINGDB

NPTX1

Tbio

Novelty:  0.02872516

p_int:  0.924588081

p_ni:  0.075411919

Data Source:  BioPlex

TMEM132A

Tdark

Novelty:  0.26489093

p_int:  0.91685433

p_ni:  0.08314567

Score:  0.181

Data Source:  BioPlex,STRINGDB

ADGRV1

Tbio

Family:  GPCR

Novelty:  0.01398129

p_int:  0.914695387

p_ni:  0.085304613

Score:  0.173

Data Source:  BioPlex,STRINGDB

CACNA2D2

Tclin

Family:  IC

Novelty:  0.02041017

p_int:  0.894872259

p_ni:  0.105127741

Score:  0.189

Data Source:  BioPlex,STRINGDB

UBR1

Tbio

Family:  Enzyme

Novelty:  0.00998888

p_int:  0.882338464

p_ni:  0.117661536

Data Source:  BioPlex

UBR2

Tbio

Family:  Enzyme

Novelty:  0.03126228

p_int:  0.755030478

p_ni:  0.244969522

Data Source:  BioPlex

CEL

Tchem

Family:  Enzyme

Novelty:  0.00156761

Score:  0.98

Data Source:  STRINGDB

LPL

Tchem

Family:  Enzyme

Novelty:  0.00057058

Score:  0.919

Data Source:  STRINGDB

Nearest Tclin Targets (5)

Explore Nearest Tclin Targets

Upstream (3)

Downstream (2)

1 – 3 of 3

DGAT1

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  3

1: Glycerolipid metabolism

2: Fat digestion and absorption

3: Metabolic pathways

PNLIP

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  4

1: Glycerolipid metabolism

2: Fat digestion and absorption

3: Metabolic pathways

4: Pancreatic secretion

LIPF

Tclin

Family:  Enzyme

KEGG Distance:  1

Common Pathways:  3

1: Glycerolipid metabolism

2: Fat digestion and absorption

3: Metabolic pathways

Pathways (7)

Reactome (3)

KEGG (4)

Digestion (R-HSA-8935690)

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Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Digestion	21 targets	R-HSA-8935690
Reactome	Digestion and absorption	26 targets	R-HSA-8963743
Reactome	Digestion of dietary lipid	7 targets	R-HSA-192456

Name	Explore in Pharos	Explore in Source
Digestion	21 targets	R-HSA-8935690
Digestion and absorption	26 targets	R-HSA-8963743
Digestion of dietary lipid	7 targets	R-HSA-192456

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Functions (2)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
triglyceride lipase activity	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	3	2	3		81
freckles	EFO_0003963	1	1	0	1.2	46.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
low density lipoprotein cholesterol measurement	EFO_0004611	3		81
freckles	EFO_0003963	0	1.2	46.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Calcium
Complete proteome
Disulfide bond
Metal-binding
Polymorphism
Reference proteome
Secreted
Signal

GWAS Trait Find Similar Targets

No Header	No Header
freckles
low density lipoprotein cholesterol measurement

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	pancreatic lipase related protein 1		700015
Mouse	pancreatic lipase related protein 1	MGI:97723	18946
Rat	pancreatic lipase-related protein 1	RGD:620792	84028
Dog	pancreatic lipase related protein 1	VGNC:44746	404010
Horse	pancreatic lipase related protein 1	VGNC:21623	100067744

Species	Name	OMA	EggNOG	Inparanoid
Macaque	pancreatic lipase related protein 1
Mouse	pancreatic lipase related protein 1
Rat	pancreatic lipase-related protein 1
Dog	pancreatic lipase related protein 1
Horse	pancreatic lipase related protein 1

Publication Statistics

PubMed Score 22.77

PubMed score by year

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PubTator Score 12.95

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title