Pharos : Target Details

Tbio

Protein Summary

Description

May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).

Uniprot Accession IDs

Gene Name

PNLIPRP1

Ensembl ID

ENST00000358834
ENSP00000351695
ENSG00000187021
ENST00000528052
ENSP00000433933

Symbol

PLRP1
PLRP1

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1

protein domain	0.92

gene perturbation	0.84

disease perturbation	0.49

kinase perturbation	0.48

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.77 (req: < 5)

View Publications

Gene RIFs: 2 (req: <= 3)

View Gene RIFs

Antibodies: 68 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.77 (req: >= 5)

Gene RIFs: 2 (req: > 3)

Antibodies: 68 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Protein-Protein Interactions (68)

1 – 10 of 68

See Interactions on String-DB

ITGA8

Tbio

Novelty: 0.0220023

p_int: 0.975402814

p_ni: 0.024153881

p_wrong: 0.000443305

Data Source: BioPlex

CEMIP2

Tbio

Novelty: 0.04698236

p_int: 0.963663778

p_ni: 0.036334561

p_wrong: 0.000001662

Score: 0.188

Data Source: BioPlex,STRINGDB

NPTX1

Tbio

Novelty: 0.02872516

p_int: 0.924588081

p_ni: 0.075411919

Data Source: BioPlex

TMEM132A

Tdark

Novelty: 0.26489093

p_int: 0.91685433

p_ni: 0.08314567

Score: 0.181

Data Source: BioPlex,STRINGDB

ADGRV1

Tbio

Family: GPCR

Novelty: 0.01398129

p_int: 0.914695387

p_ni: 0.085304613

Score: 0.173

Data Source: BioPlex,STRINGDB

CACNA2D2

Tclin

Family: IC

Novelty: 0.02041017

p_int: 0.894872259

p_ni: 0.105127741

Score: 0.189

Data Source: BioPlex,STRINGDB

UBR1

Tbio

Family: Enzyme

Novelty: 0.00998888

p_int: 0.882338464

p_ni: 0.117661536

Data Source: BioPlex

UBR2

Tbio

Family: Enzyme

Novelty: 0.03126228

p_int: 0.755030478

p_ni: 0.244969522

Data Source: BioPlex

CEL

Tchem

Family: Enzyme

Novelty: 0.00156761

Score: 0.98

Data Source: STRINGDB

LPL

Tchem

Family: Enzyme

Novelty: 0.00057058

Score: 0.919

Data Source: STRINGDB

Pathways (7)

Reactome (3)

KEGG (4)

Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Digestion	21 targets	R-HSA-8935690

Reactome	Digestion and absorption	26 targets	R-HSA-8963743

Reactome	Digestion of dietary lipid	7 targets	R-HSA-192456

Name	Explore in Pharos	Explore in Source
Digestion	21 targets	R-HSA-8935690

Digestion and absorption	26 targets	R-HSA-8963743

Digestion of dietary lipid	7 targets	R-HSA-192456

Gene Ontology Terms (4)

Functions (2)

Components (1)

Processes (1)

Items per page:

1 – 2 of 2

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB

triglyceride lipase activity	Traceable Author Statement (TAS)	ProtInc

GWAS Traits (2)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
low density lipoprotein cholesterol measurement	EFO_0004611	3	2	3		81

freckles	EFO_0003963	1	1	0	1.2	46.1

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
low density lipoprotein cholesterol measurement	EFO_0004611	3		81

freckles	EFO_0003963	0	1.2	46.1

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

No Header	No Header
3D-structure

Alternative splicing

Calcium

Complete proteome

Disulfide bond

Metal-binding

Polymorphism

Reference proteome

Secreted

Signal

GWAS Trait

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID
Macaque	pancreatic lipase related protein 1		700015

Mouse	pancreatic lipase related protein 1	MGI:97723	18946

Rat	pancreatic lipase-related protein 1	RGD:620792	84028

Dog	pancreatic lipase related protein 1	VGNC:44746	404010

Horse	pancreatic lipase related protein 1	VGNC:21623	100067744

Species	Name	OMA	EggNOG	Inparanoid
Macaque	pancreatic lipase related protein 1

Mouse	pancreatic lipase related protein 1

Rat	pancreatic lipase-related protein 1

Dog	pancreatic lipase related protein 1

Horse	pancreatic lipase related protein 1

Publication Statistics

PubMed Score 22.77

PubMed score by year

PubTator Score 12.95

PubTator score by year