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Tbio
PNLIPRP1
Inactive pancreatic lipase-related protein 1

Protein Summary
Description
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro) (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358834
  • ENSP00000351695
  • ENSG00000187021
  • ENST00000528052
  • ENSP00000433933

Symbol
  • PLRP1
  • PLRP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
protein domain
0.92
gene perturbation
0.84
disease perturbation
0.49
kinase perturbation
0.48


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.77   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.77   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
ITGA8
Tbio
Novelty:  0.0220023
p_int:  0.975402814
p_ni:  0.024153881
p_wrong:  0.000443305
Data Source:  BioPlex
CEMIP2
Tbio
Novelty:  0.04698236
p_int:  0.963663778
p_ni:  0.036334561
p_wrong:  0.000001662
Score:  0.188
Data Source:  BioPlex,STRINGDB
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.924588081
p_ni:  0.075411919
Data Source:  BioPlex
TMEM132A
Tdark
Novelty:  0.26489093
p_int:  0.91685433
p_ni:  0.08314567
Score:  0.181
Data Source:  BioPlex,STRINGDB
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.914695387
p_ni:  0.085304613
Score:  0.173
Data Source:  BioPlex,STRINGDB
CACNA2D2
Tclin
Family:  IC
Novelty:  0.02041017
p_int:  0.894872259
p_ni:  0.105127741
Score:  0.189
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.882338464
p_ni:  0.117661536
Data Source:  BioPlex
UBR2
Tbio
Family:  Enzyme
Novelty:  0.03126228
p_int:  0.755030478
p_ni:  0.244969522
Data Source:  BioPlex
CEL
Tchem
Family:  Enzyme
Novelty:  0.00156761
Score:  0.98
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
Pathways (7)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Reactome
Digestion of dietary lipid
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Digestion of dietary lipid
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
2
3
81
freckles
1
1
0
1.2
46.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
81
freckles
0
1.2
46.1
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
pancreatic lipase related protein 1
700015
Mouse
MGI:97723
18946
Rat
RGD:620792
84028
Dog
pancreatic lipase related protein 1
VGNC:44746
404010
Horse
pancreatic lipase related protein 1
VGNC:21623
100067744
Species
Name
OMA
EggNOG
Inparanoid
Macaque
pancreatic lipase related protein 1
Mouse
Rat
Dog
pancreatic lipase related protein 1
Horse
pancreatic lipase related protein 1
Publication Statistics
PubMed Score 22.77
PubMed score by year
PubTator Score 12.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title