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Tbio
MYOM2
Myomesin-2

Protein Summary
Description
Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262113
  • ENSP00000262113
  • ENSG00000036448
  • ENST00000616680
  • ENSP00000478322
  • ENSG00000274137

Symbol
  • TTNAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.83
PubMedID
0.75
cell type or tissue
0.66
cellular component
0.58


Related Tools
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ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3085.41   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3085.41   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myomesin 2
VGNC:50316
472687
Macaque
myomesin 2
716555
Mouse
MGI:1328358
17930
Rat
RGD:631437
306616
Horse
myomesin 2
VGNC:20520
100065193
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myomesin 2
Macaque
myomesin 2
Mouse
Rat
Horse
myomesin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P54296-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (132)
1 – 10 of 132
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.999877642
p_ni: 1.1e-8
p_wrong: 0.000122347
Data Source: BioPlex
TTN
Tbio
Family: Kinase
Novelty: 0.00040356
Score: 0.923
Data Source: STRINGDB
MYL1
Tbio
Novelty: 0.00360262
Score: 0.841
Data Source: STRINGDB
MYOZ2
Tbio
Novelty: 0.04557513
Score: 0.821
Data Source: STRINGDB
MYH9
Tbio
Novelty: 0.0016488
Score: 0.79
Data Source: STRINGDB
MYH6
Tbio
Novelty: 0.00058671
Score: 0.781
Data Source: STRINGDB
MYH7
Tbio
Novelty: 0.00268092
Score: 0.78
Data Source: STRINGDB
MYL3
Tbio
Novelty: 0.00493817
Score: 0.778
Data Source: STRINGDB
CMYA5
Tbio
Novelty: 0.05675889
Score: 0.773
Data Source: STRINGDB
GP5
Tbio
Novelty: 0.00095584
Score: 0.767
Data Source: STRINGDB
Publication Statistics
PubMed Score  3085.41

PubMed score by year
PubTator Score  723.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer