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Tclin
CACNA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

Protein Summary
Description
The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356253
  • ENSP00000348589
  • ENSG00000153956
  • ENST00000356860
  • ENSP00000349320

Symbol
  • CACNL2A
  • CCHL2A
  • MHS3
  • CACNA2
  • CCHL2A
  • CACNL2A
  • LINC01112
  • lncRNA-N3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
molecular function
0.91
transcription factor perturbation
0.91
PubMedID
0.8
co-expressed gene
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.89   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.89   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 144
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
feeling nervous measurement
1
1
0
5.7
16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
feeling nervous measurement
0
5.7
16
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit alpha2delta 1
VGNC:8674
463504
Mouse
MGI:88295
12293
Rat
RGD:2247
25399
Dog
calcium voltage-gated channel auxiliary subunit alpha2delta 1
VGNC:38641
610342
Horse
calcium voltage-gated channel auxiliary subunit alpha2delta 1
VGNC:15988
100057533
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit alpha2delta 1
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit alpha2delta 1
Horse
calcium voltage-gated channel auxiliary subunit alpha2delta 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P54289-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 0 - rapid depolarisation
Reactome
Phase 2 - plateau phase
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 0 - rapid depolarisation
Phase 2 - plateau phase
Gene Ontology Terms (20)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (163)
1 – 10 of 163
SCGB1D4
Tdark
Novelty: 0.15597658
p_int: 0.999539044
p_ni: 0.000460956
Data Source: BioPlex
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.999468794
p_ni: 0.000531206
Data Source: BioPlex
NDP
Tbio
Novelty: 0.01020963
p_int: 0.99860819
p_ni: 0.00139181
Data Source: BioPlex
PRSS33
Tbio
Family: Enzyme
Novelty: 0.6231111
p_int: 0.998605256
p_ni: 0.001394744
Score: 0.189
Data Source: BioPlex,STRINGDB
APOC3
Tclin
Novelty: 0.0009635
p_int: 0.998567935
p_ni: 0.001432065
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.997892626
p_ni: 0.002107374
Data Source: BioPlex
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
p_int: 0.997831816
p_ni: 0.002168184
Score: 0.177
Data Source: BioPlex,STRINGDB
EDDM3B
Tdark
Novelty: 0.12874735
p_int: 0.996962314
p_ni: 0.003037686
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.996767382
p_ni: 0.003232618
Data Source: BioPlex
CCL19
Tbio
Novelty: 0.00169711
p_int: 0.992184999
p_ni: 0.007815001
Data Source: BioPlex
Publication Statistics
PubMed Score  49.89

PubMed score by year
PubTator Score  20.83

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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