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Tbio
CACNB3
Voltage-dependent L-type calcium channel subunit beta-3

Protein Summary
Description
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301050
  • ENSP00000301050
  • ENSG00000167535
  • ENST00000536187
  • ENSP00000444160
  • ENST00000540990
  • ENSP00000445495
  • ENST00000547230
  • ENSP00000448304

Symbol
  • CACNLB3
  • CAB3
  • CACNLB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
hub protein
0.88
disease perturbation
0.87
PubMedID
0.81
transcription factor binding site profile
0.78


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit beta 3
VGNC:8353
451867
Macaque
calcium voltage-gated channel auxiliary subunit beta 3
708091
Mouse
MGI:103307
12297
Rat
RGD:2248
25297
Dog
calcium voltage-gated channel auxiliary subunit beta 3
VGNC:38646
486563
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel auxiliary subunit beta 3
Macaque
calcium voltage-gated channel auxiliary subunit beta 3
Mouse
Rat
Dog
calcium voltage-gated channel auxiliary subunit beta 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P54284-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Adrenaline,noradrenaline inhibits insulin secretion (R-HSA-400042)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Integration of energy metabolism
Name
Explore in Pharos
Explore in Source
Adrenaline,noradrenaline inhibits insulin secretion
Axon guidance
Cardiac conduction
Developmental Biology
Integration of energy metabolism
Gene Ontology Terms (29)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (125)
1 – 10 of 125
CACNB2
Tbio
Family: IC
Novelty: 0.01745218
p_int: 0.999999974
p_wrong: 2.6e-8
Score: 0.952
Data Source: BioPlex,STRINGDB
CACNB1
Tbio
Family: IC
Novelty: 0.06568749
p_int: 0.999999897
p_ni: 1.03e-7
Score: 0.93
Data Source: BioPlex,STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.01564026
p_int: 0.999996984
p_ni: 0.000003016
Score: 0.94
Data Source: BioPlex,STRINGDB
CBARP
Tbio
Novelty: 0.04783435
p_int: 0.999989452
p_ni: 0.000010547
p_wrong: 1e-9
Score: 0.808
Data Source: BioPlex,STRINGDB
CIAPIN1
Tbio
Novelty: 0.01359005
p_int: 0.999981471
p_ni: 0.000018529
Score: 0.323
Data Source: BioPlex,STRINGDB
ZFY
Tdark
Family: TF
p_int: 0.999685531
p_ni: 0.000314469
Data Source: BioPlex
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
p_int: 0.999281226
p_ni: 0.000718774
Data Source: BioPlex
WDR45B
Tbio
Novelty: 0.22407227
p_int: 0.997189081
p_ni: 0.002810919
Score: 0.167
Data Source: BioPlex,STRINGDB
CACNA1B
Tclin
Family: IC
Novelty: 0.00319692
Score: 0.988
Data Source: Reactome,STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.02238343
Score: 0.983
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  24.69

PubMed score by year
PubTator Score  4.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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