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Tbio
TERF1
Telomeric repeat-binding factor 1

Protein Summary
Description
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276602
  • ENSP00000276602
  • ENSG00000147601
  • ENST00000276603
  • ENSP00000276603

Symbol
  • PIN2
  • TRBF1
  • TRF
  • TRF1
  • TRF
  • PIN2
  • TRF1
  • TRBF1
  • t-TRF1
  • hTRF1-AS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
1
virus perturbation
0.92
transcription factor perturbation
0.84
kinase
0.8
biological process
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 705.53   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 621   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 705.53   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 621   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0