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Tbio
HAP1
Huntingtin-associated protein 1

Protein Summary
Description
Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric ac ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310778
  • ENSP00000309392
  • ENSG00000173805
  • ENST00000341193
  • ENSP00000343170
  • ENST00000347901
  • ENSP00000334002
  • ENST00000393939
  • ENSP00000377513

Symbol
  • HAP2
  • HLP1
  • HLP
  • HAP2
  • HIP5
  • hHLP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
kinase perturbation
0.81
histone modification site profile
0.78
cellular component
0.67
hub protein
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.07   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.07   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
27.6
1
1
0
1.3
27.6
viral load
1
1
1
8.4
HIV-1 infection
1
1
1
8.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
27.6
0
1.3
27.6
viral load
1
8.4
HIV-1 infection
1
8.4
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1261831
15114
Rat
RGD:68327
29430
Dog
huntingtin associated protein 1
VGNC:41592
607751
Horse
huntingtin associated protein 1 [Source:HGNC Symbol;Acc:HGNC:4812]
Pig
huntingtin associated protein 1
100736934
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
huntingtin associated protein 1
Horse
huntingtin associated protein 1 [Source:HGNC Symbol;Acc:HGNC:4812]
Pig
huntingtin associated protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P54257-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (46)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (60)
1 – 10 of 60
HTT
Tchem
Novelty: 0.00034051
Score: 0.901
Data Source: STRINGDB
NFYB
Tbio
Family: TF
Novelty: 0.00419747
Score: 0.888
Data Source: STRINGDB
REPIN1
Tbio
Family: TF
Novelty: 0.01152362
Score: 0.867
Data Source: STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.865
Data Source: STRINGDB
KALRN
Tbio
Family: Kinase
Novelty: 0.01111401
Score: 0.84
Data Source: STRINGDB
AHI1
Tbio
Novelty: 0.01180688
Score: 0.839
Data Source: STRINGDB
GABRB1
Tclin
Family: IC
Novelty: 0.02895574
Score: 0.772
Data Source: STRINGDB
GABRB2
Tclin
Family: IC
Novelty: 0.01954146
Score: 0.756
Data Source: STRINGDB
NFYC
Tbio
Family: TF
Novelty: 0.00626931
Score: 0.751
Data Source: STRINGDB
GABRA1
Tclin
Family: IC
Novelty: 0.0094079
Score: 0.747
Data Source: STRINGDB
Publication Statistics
PubMed Score  150.07

PubMed score by year
PubTator Score  158.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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