Protein Summary
Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (PubMed:12297501, PubMed:17696782, PubMed:23625928, PubMed:28445460, PubMed:16118278). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (PubMed:17696782). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (PubMed:12297501). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (PubMed:28445460). Machado-Joseph disease, also known as spinocerebel ...more
- ENST00000340660
- ENSP00000339110
- ENSG00000066427
- ENST00000502250
- ENSP00000425322
- ENST00000503767
- ENSP00000426697
- ENST00000532032
- ENSP00000437157
- ENST00000558190
- ENSP00000478320
- ENST00000644486
- ENSP00000496695
- ATX3
- MJD
- MJD1
- SCA3
- AT3
- JOS
- MJD
- ATX3
- MJD1
- SCA3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
co-expressed gene | 1 | ||
microRNA | 0.84 | ||
biological process | 0.8 | ||
virus perturbation | 0.79 | ||
transcription factor binding site profile | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 550.97 (req: < 5)
Gene RIFs: 153 (req: <= 3)
Antibodies: 302 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 550.97 (req: >= 5)
Gene RIFs: 153 (req: > 3)
Antibodies: 302 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (157)
TOMM20L
Novelty: 4.50556416
p_int: 0.999999999
p_ni: 1e-9
Score: 0.485
Data Source: BioPlex,STRINGDB
IGF2
Novelty: 0.00021277
p_int: 0.999996585
p_ni: 0.000002867
p_wrong: 5.48e-7
Data Source: BioPlex
TMEM31
Novelty: 0.65381391
p_int: 0.999992214
p_ni: 0.000005918
p_wrong: 0.000001868
Data Source: BioPlex
DND1
Novelty: 0.0287312
p_int: 0.999412306
p_ni: 0.000028795
p_wrong: 0.000558899
Score: 0.269
Data Source: BioPlex,STRINGDB
AEBP2
Novelty: 0.05974483
p_int: 0.999131187
p_ni: 0.000045903
p_wrong: 0.00082291
Score: 0.308
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (9)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Deubiquitination | ||||
Reactome | FOXO-mediated transcription | ||||
Reactome | FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Deubiquitination | ||||
FOXO-mediated transcription | ||||
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes | ||||
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (39)
Functions (9)
Components (10)
Processes (20)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Direct Assay (IDA) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
body height | 6 | 6 | 6 | 5.7 | 98.2 | ||||
BMI-adjusted waist circumference | 5 | 6 | 8 | 74.4 | |||||
BMI-adjusted hip circumference | 1 | 3 | 3 | 72.6 | |||||
Myopia | 2 | 2 | 0 | 3.8 | 72.4 | ||||
forced expiratory volume | 2 | 2 | 2 | 68.5 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
body height | 6 | 5.7 | 98.2 | ||||
BMI-adjusted waist circumference | 8 | 74.4 | |||||
BMI-adjusted hip circumference | 3 | 72.6 | |||||
Myopia | 0 | 3.8 | 72.4 | ||||
forced expiratory volume | 2 | 68.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ataxin 3 | VGNC:12976 | 738729 | |||||
Macaque | ataxin 3 | 720515 | ||||||
Mouse | MGI:1099442 | 110616 | ||||||
Rat | RGD:621567 | 60331 | ||||||
Dog | ataxin 3 | 480229 | ||||||
Publication Statistics
PubMed Score 550.97
PubMed score by year
PubTator Score 854.70
PubTator score by year
Related Publications
Text Mined References (200)
GeneRif Annotations (153)
Items per page:
0 of 0
PMID | Year | Title |
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