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Tchem
SLC18A1
Chromaffin granule amine transporter

Protein Summary
Description
Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265808
  • ENSP00000265808
  • ENSG00000036565
  • ENST00000276373
  • ENSP00000276373
  • ENST00000381608
  • ENSP00000371021
  • ENST00000437980
  • ENSP00000413361
  • ENST00000440926
  • ENSP00000387549
  • ENST00000519026
  • ENSP00000429664

Symbol
  • VAT1
  • VMAT1
  • CGAT
  • VAT1
  • VMAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
PubMedID
0.56
cell type or tissue
0.5
chemical
0.49
cellular component
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.53   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.53   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2