You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SLC18A1
Chromaffin granule amine transporter

Protein Summary
Description
Involved in the transport of biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles of neuroendocrine and endocrine cells. The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265808
  • ENSP00000265808
  • ENSG00000036565
  • ENST00000276373
  • ENSP00000276373
  • ENST00000381608
  • ENSP00000371021
  • ENST00000437980
  • ENSP00000413361
  • ENST00000440926
  • ENSP00000387549
  • ENST00000519026
  • ENSP00000429664

Symbol
  • VAT1
  • VMAT1
  • CGAT
  • VAT1
  • VMAT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
PubMedID
0.56
cell type or tissue
0.5
chemical
0.49
cellular component
0.48


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.06   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.06   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (83)
ZMPSTE24
Tbio
Family:  Enzyme
Novelty:  0.0027993
p_int:  0.999332915
p_ni:  0.000667085
Data Source:  BioPlex
EMC4
Tbio
Novelty:  0.12174476
p_int:  0.992704041
p_ni:  0.007228828
p_wrong:  0.000067131
Score:  0.158
Data Source:  BioPlex,STRINGDB
HSD17B7
Tchem
Family:  Enzyme
Novelty:  0.04295724
p_int:  0.991347054
p_ni:  0.008626681
p_wrong:  0.000026265
Data Source:  BioPlex
OTULIN
Tbio
Family:  Enzyme
Novelty:  0.04694238
p_int:  0.990370688
p_ni:  0.008834145
p_wrong:  0.000795167
Data Source:  BioPlex
GJC1
Tbio
Novelty:  0.00375192
p_int:  0.984271833
p_ni:  0.015215178
p_wrong:  0.000512989
Data Source:  BioPlex
PDK1
Tchem
Family:  Kinase
Novelty:  0.0078496
p_int:  0.982652996
p_ni:  0.017345208
p_wrong:  0.000001796
Data Source:  BioPlex
PXMP2
Tbio
Novelty:  0.24472872
p_int:  0.982531505
p_ni:  0.017444464
p_wrong:  0.000024031
Data Source:  BioPlex
DPH6
Tbio
Family:  Enzyme
Novelty:  0.15211179
p_int:  0.98059379
p_ni:  0.005752648
p_wrong:  0.013653563
Data Source:  BioPlex
FADS1
Tchem
Family:  Enzyme
Novelty:  0.00160193
p_int:  0.976420335
p_ni:  0.022329215
p_wrong:  0.001250449
Data Source:  BioPlex
ECPAS
Tbio
Novelty:  0.04004664
p_int:  0.963326342
p_ni:  0.036673658
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Na+/Cl- dependent neurotransmitter transporters (R-HSA-442660)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Na+/Cl- dependent neurotransmitter transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Na+/Cl- dependent neurotransmitter transporters
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
11
19
36
7.8
99.7
high density lipoprotein cholesterol measurement
7
22
32
2.2
99.7
sleep duration
3
5
5
96
apolipoprotein A 1 measurement
2
7
7
94.3
red blood cell distribution width
4
2
5
86.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
36
7.8
99.7
high density lipoprotein cholesterol measurement
32
2.2
99.7
sleep duration
5
96
apolipoprotein A 1 measurement
7
94.3
red blood cell distribution width
5
86.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 18 member A1
VGNC:7739
464032
Macaque
solute carrier family 18 member A1
705489
Mouse
MGI:106684
110877
Rat
RGD:3693
25693
Dog
solute carrier family 18 member A1
VGNC:46255
486138
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 18 member A1
Macaque
solute carrier family 18 member A1
Mouse
Rat
Dog
solute carrier family 18 member A1
Publication Statistics
PubMed Score 87.06
PubMed score by year
PubTator Score 61.98
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title