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Tbio
HIRA
Protein HIRA

Protein Summary
Description
Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263208
  • ENSP00000263208
  • ENSG00000100084
  • ENST00000340170
  • ENSP00000345350

Symbol
  • DGCR1
  • HIR
  • TUPLE1
  • TUP1
  • DGCR1
  • TUPLE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
histone modification site profile
0.85
protein domain
0.85
interacting protein
0.81
transcription factor perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.01   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.01   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
719142
Mouse
MGI:99430
15260
Rat
RGD:6490647
100911837
Dog
histone cell cycle regulator
VGNC:50634
486424
Horse
histone cell cycle regulator
VGNC:50598
100052845
Species
Name
OMA
EggNOG
Inparanoid
Macaque
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
Mouse
Rat
Dog
histone cell cycle regulator
Horse
histone cell cycle regulator
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P54198-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
DNA Damage/Telomere Stress Induced Senescence
Reactome
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
DNA Damage/Telomere Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Protein-Protein Interactions (128)
1 – 10 of 128
ASF1B
Tbio
Novelty: 0.05716701
p_int: 0.999999957
p_ni: 2e-8
p_wrong: 2.3e-8
Score: 0.921
Data Source: BioPlex,STRINGDB
ASF1A
Tchem
Novelty: 0.02544466
p_int: 0.999999945
p_ni: 5.1e-8
p_wrong: 4e-9
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
TFAP4
Tbio
Family: TF
Novelty: 0.03155887
p_int: 0.99997226
p_ni: 0.000027739
p_wrong: 1e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
HMGA1
Tbio
Family: TF
Novelty: 0.00185669
p_int: 0.999969331
p_ni: 0.000030669
Score: 0.902
Data Source: BioPlex,Reactome,STRINGDB
CDX1
Tbio
Family: TF
Novelty: 0.00815821
p_int: 0.99994318
p_ni: 0.00005682
Data Source: BioPlex
XAGE1A
Tbio
Novelty: 0.04421526
p_int: 0.999604226
p_ni: 0.000395774
Data Source: BioPlex
HIST1H3A
Tbio
Novelty: 0.00991842
p_int: 0.996178936
p_ni: 0.003821062
p_wrong: 2e-9
Score: 0.387
Data Source: BioPlex,STRINGDB
TEAD2
Tbio
Family: TF
Novelty: 0.02487024
p_int: 0.985780568
p_ni: 0.014099947
p_wrong: 0.000119485
Score: 0.195
Data Source: BioPlex,STRINGDB
SP4
Tbio
Family: TF
Novelty: 0.02444442
p_int: 0.973204489
p_ni: 0.026568936
p_wrong: 0.000226576
Score: 0.34
Data Source: BioPlex,STRINGDB
ZBTB48
Tbio
Family: TF
Novelty: 0.07020518
p_int: 0.958141137
p_ni: 0.034407292
p_wrong: 0.00745157
Score: 0.171
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  69.01

PubMed score by year
PubTator Score  94.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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