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Tchem
POLG
DNA polymerase subunit gamma-1

Protein Classes
Protein Summary
Description
Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA. Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268124
  • ENSP00000268124
  • ENSG00000140521
  • ENST00000442287
  • ENSP00000399851

Symbol
  • MDP1
  • POLG1
  • POLGA
  • PEO
  • MDP1
  • SCAE
  • MIRAS
  • POLG1
  • POLGA
  • SANDO
  • MTDPS4A
  • MTDPS4B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.96
transcription factor binding site profile
0.96
virus perturbation
0.9
interacting protein
0.86
disease
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 603.2   (req: < 5)
Gene RIFs: 221   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 603.2   (req: >= 5)
Gene RIFs: 221   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL483492
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
1
1
71.6
body height
1
1
1
59.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
1
71.6
body height
1
59.7
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (156)
1 – 10 of 156
POLG2
Tbio
Family: Enzyme
Novelty: 0.0233323
p_int: 0.999999992
p_ni: 8e-9
Score: 0.983
Data Source: BioPlex,STRINGDB
NIT1
Tbio
Family: Enzyme
Novelty: 0.00498587
p_int: 0.999683718
p_ni: 0.000316281
Score: 0.158
Data Source: BioPlex,STRINGDB
MGME1
Tbio
Family: Enzyme
Novelty: 0.05284418
p_int: 0.999428278
p_ni: 0.000571722
Score: 0.659
Data Source: BioPlex,STRINGDB
GLB1L3
Tdark
Family: Enzyme
Novelty: 1.00833616
p_int: 0.999277175
p_ni: 0.000722825
Score: 0.167
Data Source: BioPlex,STRINGDB
BPNT1
Tbio
Family: Enzyme
Novelty: 0.1114547
p_int: 0.998205873
p_ni: 0.001794127
p_wrong: 1e-9
Data Source: BioPlex
MRPS18B
Tbio
Novelty: 0.14519418
p_int: 0.997765767
p_ni: 0.002234233
Data Source: BioPlex
OTC
Tchem
Family: Enzyme
Novelty: 0.00544004
p_int: 0.997340269
p_ni: 0.002659731
Score: 0.258
Data Source: BioPlex,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.992184382
p_ni: 0.007815227
p_wrong: 3.9e-7
Score: 0.256
Data Source: BioPlex,STRINGDB
ACSM5
Tbio
Family: Enzyme
Novelty: 0.11562771
p_int: 0.988944885
p_ni: 0.011055115
Score: 0.191
Data Source: BioPlex,STRINGDB
YBEY
Tdark
Family: Enzyme
Novelty: 0.02778029
p_int: 0.988561028
p_ni: 0.011438942
p_wrong: 3e-8
Score: 0.194
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  603.20

PubMed score by year
PubTator Score  425.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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