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Tbio
SEC24C
Protein transport protein Sec24C

Protein Summary
Description
Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339365
  • ENSP00000343405
  • ENSG00000176986
  • ENST00000345254
  • ENSP00000321845

Symbol
  • KIAA0079
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
protein domain
0.92
transcription factor binding site profile
0.9
histone modification site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.73   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.73   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
visceral adipose tissue measurement
1
1
1
66.2
self rated health
1
1
1
31.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
visceral adipose tissue measurement
1
66.2
self rated health
1
31.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SEC24 homolog C, COPII coat complex component
VGNC:5721
450525
Macaque
SEC24 homolog C, COPII coat complex component
714688
Mouse
MGI:1919746
218811
Rat
RGD:1597739
685144
Dog
SEC24 homolog C, COPII coat complex component
VGNC:45974
100855957
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SEC24 homolog C, COPII coat complex component
Macaque
SEC24 homolog C, COPII coat complex component
Mouse
Rat
Dog
SEC24 homolog C, COPII coat complex component
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P53992-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
Cargo concentration in the ER
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
Cargo concentration in the ER
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (266)
1 – 10 of 266
SEC23B
Tbio
Novelty: 0.02307622
p_int: 0.996264106
p_ni: 0.003735895
Score: 0.992
Data Source: BioPlex,STRINGDB
SEC23A
Tbio
Novelty: 0.0384262
Score: 0.998
Data Source: Reactome,STRINGDB
SEC24A
Tbio
Novelty: 0.07724534
Score: 0.997
Data Source: Reactome,STRINGDB
SEC16A
Tbio
Novelty: 0.02221416
Score: 0.995
Data Source: Reactome,STRINGDB
SEC24D
Tbio
Novelty: 0.04795527
Score: 0.994
Data Source: Reactome,STRINGDB
SEC13
Tbio
Novelty: 0.00709413
Score: 0.992
Data Source: Reactome,STRINGDB
SEC31A
Tbio
Novelty: 0.0350228
Score: 0.991
Data Source: Reactome,STRINGDB
SEC16B
Tbio
Novelty: 0.04073621
Score: 0.991
Data Source: Reactome,STRINGDB
SEC31B
Tdark
Novelty: 0.35742768
Score: 0.985
Data Source: STRINGDB
SAR1A
Tbio
Family: Enzyme
Novelty: 0.0335242
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.73

PubMed score by year
PubTator Score  9.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer