Tbio IST1 IST1 homolog

Protein Summary

Description

ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• P53990
• A8KAH5
• J3QLU7
• Q3SYM4
• Q9BQ81
• Q9BWN2
• hIST1

Gene Name

• IST1

Ensembl ID

• ENST00000329908
• ENSP00000330408
• ENSG00000182149
• ENST00000378798
• ENSP00000368075
• ENST00000378799
• ENSP00000368076
• ENST00000535424
• ENSP00000438399
• ENST00000538850
• ENSP00000463711
• ENST00000541571
• ENSP00000455860
• ENST00000544564
• ENSP00000457844
• ENST00000606369
• ENSP00000475853

Symbol

• KIAA0174
• OLC1
• CHMP8

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.98
disease perturbation	0.97
virus perturbation	0.92
co-expressed gene	0.89
kinase perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.82   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.82   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0