SLC16A1
Monocarboxylate transporter 1
Protein Classes
Protein Summary
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plas ...more
- ENST00000369626
- ENSP00000358640
- ENSG00000155380
- ENST00000538576
- ENSP00000441065
- ENST00000628110
- ENSP00000485688
- ENSG00000281917
- ENST00000630362
- ENSP00000486000
- MCT1
- MCT
- HHF7
- MCT1
- MCT1D
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
transcription factor binding site profile | 0.92 | ||
kinase perturbation | 0.91 | ||
drug | 0.89 | ||
histone modification site profile | 0.86 | ||
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 319.24 (req: < 5)
Gene RIFs: 116 (req: <= 3)
Antibodies: 285 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 319.24 (req: >= 5)
Gene RIFs: 116 (req: > 3)
Antibodies: 285 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 65
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (65)
1 – 10 of 65
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
refractive error measurement | 1 | 1 | 1 | 74.2 | ||||||
refractive error measurement | 1 | 1 | 1 | 74.2 | ||||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
refractive error measurement | 1 | 74.2 | |||||
refractive error measurement | 1 | 74.2 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | solute carrier family 16 member 1 | 706593 | ||||||
Mouse | MGI:106013 | 20501 | ||||||
Rat | RGD:3690 | 25027 | ||||||
Dog | solute carrier family 16 member 1 | VGNC:46235 | 475856 | |||||
Horse | solute carrier family 16 member 1 | VGNC:50886 | 100009694 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | solute carrier family 16 member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | solute carrier family 16 member 1 | |||||
Horse | solute carrier family 16 member 1 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (41)
Reactome (15)
PathwayCommons (1)
WikiPathways (25)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 15
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Basigin interactions | ||||
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Basigin interactions | ||||
Cell surface interactions at the vascular wall | ||||
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
Gene Ontology Terms (27)
Functions (6)
Components (9)
Processes (12)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (55)
1 – 10 of 55
BSG
Novelty: 0.0010285
Score: 0.986
Data Source: Reactome,STRINGDB
SLC18B1
Family: Transporter
Novelty: 0.25084245
Score: 0.802
Data Source: STRINGDB
SLC18A1
Family: Transporter
Novelty: 0.01135292
Score: 0.759
Data Source: STRINGDB
SLC5A8
Family: Transporter
Novelty: 0.00892277
Score: 0.691
Data Source: STRINGDB
LDHA
Family: Enzyme
Novelty: 0.0007041
Score: 0.68
Data Source: STRINGDB
TENT5A
Novelty: 0.08412895
Score: 0.673
Data Source: STRINGDB
SLC39A9
Family: Transporter
Novelty: 0.06143625
Score: 0.66
Data Source: STRINGDB
SLC17A1
Family: Transporter
Novelty: 0.0127372
Score: 0.653
Data Source: STRINGDB
SLC2A1
Family: Transporter
Novelty: 0.00027583
Score: 0.642
Data Source: STRINGDB
SLC39A8
Family: Transporter
Novelty: 0.00923197
Score: 0.637
Data Source: STRINGDB
Publication Statistics
PubMed Score 319.24
PubMed score by year
PubTator Score 396.45
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword