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Tchem
SLC16A1
Monocarboxylate transporter 1

Protein Summary
Description
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plas ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369626
  • ENSP00000358640
  • ENSG00000155380
  • ENST00000538576
  • ENSP00000441065
  • ENST00000628110
  • ENSP00000485688
  • ENSG00000281917
  • ENST00000630362
  • ENSP00000486000

Symbol
  • MCT1
  • MCT
  • HHF7
  • MCT1
  • MCT1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor binding site profile
0.92
kinase perturbation
0.91
drug
0.89
histone modification site profile
0.86


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.24   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.24   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 65
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (65)
1 – 10 of 65
CHEMBL3818005
chemical structure image
CHEMBL3326252
chemical structure image
CHEMBL3819158
chemical structure image
CHEMBL3326259
chemical structure image
CHEMBL3326256
chemical structure image
CHEMBL3819278
chemical structure image
CHEMBL3818991
chemical structure image
CHEMBL3818476
chemical structure image
CHEMBL3326265
chemical structure image
CHEMBL219311
chemical structure image
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
1
1
74.2
refractive error measurement
1
1
1
74.2
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
74.2
refractive error measurement
1
74.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 16 member 1
706593
Mouse
MGI:106013
20501
Rat
RGD:3690
25027
Dog
solute carrier family 16 member 1
VGNC:46235
475856
Horse
solute carrier family 16 member 1
VGNC:50886
100009694
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 16 member 1
Mouse
Rat
Dog
solute carrier family 16 member 1
Horse
solute carrier family 16 member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P53985-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (41)
Basigin interactions (R-HSA-210991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
Basigin interactions
Cell surface interactions at the vascular wall
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
Disease
Disorders of transmembrane transporters
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
BSG
Tbio
Novelty: 0.0010285
Score: 0.986
Data Source: Reactome,STRINGDB
SLC18B1
Tdark
Family: Transporter
Novelty: 0.25084245
Score: 0.802
Data Source: STRINGDB
SLC18A1
Tchem
Family: Transporter
Novelty: 0.01135292
Score: 0.759
Data Source: STRINGDB
SLC5A8
Tchem
Family: Transporter
Novelty: 0.00892277
Score: 0.691
Data Source: STRINGDB
LDHA
Tchem
Family: Enzyme
Novelty: 0.0007041
Score: 0.68
Data Source: STRINGDB
TENT5A
Tbio
Novelty: 0.08412895
Score: 0.673
Data Source: STRINGDB
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
Score: 0.66
Data Source: STRINGDB
SLC17A1
Tbio
Family: Transporter
Novelty: 0.0127372
Score: 0.653
Data Source: STRINGDB
SLC2A1
Tchem
Family: Transporter
Novelty: 0.00027583
Score: 0.642
Data Source: STRINGDB
SLC39A8
Tbio
Family: Transporter
Novelty: 0.00923197
Score: 0.637
Data Source: STRINGDB
Publication Statistics
PubMed Score  319.24

PubMed score by year
PubTator Score  396.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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