You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SLC16A1
Monocarboxylate transporter 1

Protein Summary
Description
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plas ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369626
  • ENSP00000358640
  • ENSG00000155380
  • ENST00000538576
  • ENSP00000441065
  • ENST00000628110
  • ENSP00000485688
  • ENSG00000281917
  • ENST00000630362
  • ENSP00000486000

Symbol
  • MCT1
  • MCT
  • HHF7
  • MCT1
  • MCT1D
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
transcription factor binding site profile
0.92
kinase perturbation
0.91
drug
0.89
histone modification site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.33   (req: < 5)
Gene RIFs: 116   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 337.33   (req: >= 5)
Gene RIFs: 116   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 65
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (65)
CHEMBL205807
Rendered image for CHEMBL205807
CHEMBL219483
Rendered image for CHEMBL219483
CHEMBL378405
Rendered image for CHEMBL378405
CHEMBL379399
Rendered image for CHEMBL379399
CHEMBL205845
Rendered image for CHEMBL205845
CHEMBL205526
Rendered image for CHEMBL205526
CHEMBL218573
Rendered image for CHEMBL218573
CHEMBL205742
Rendered image for CHEMBL205742
CHEMBL380192
Rendered image for CHEMBL380192
CHEMBL3818777
Rendered image for CHEMBL3818777
Protein-Protein Interactions (55)
BSG
Tbio
Novelty:  0.0010285
Score:  0.986
Data Source:  Reactome,STRINGDB
SLC18B1
Tdark
Family:  Transporter
Novelty:  0.25084245
Score:  0.802
Data Source:  STRINGDB
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
Score:  0.759
Data Source:  STRINGDB
SLC5A8
Tchem
Family:  Transporter
Novelty:  0.00892277
Score:  0.691
Data Source:  STRINGDB
LDHA
Tchem
Family:  Enzyme
Novelty:  0.0007041
Score:  0.68
Data Source:  STRINGDB
TENT5A
Tbio
Novelty:  0.08412895
Score:  0.673
Data Source:  STRINGDB
SLC39A9
Tbio
Family:  Transporter
Novelty:  0.06143625
Score:  0.66
Data Source:  STRINGDB
SLC17A1
Tbio
Family:  Transporter
Novelty:  0.0127372
Score:  0.653
Data Source:  STRINGDB
SLC2A1
Tchem
Family:  Transporter
Novelty:  0.00027583
Score:  0.642
Data Source:  STRINGDB
SLC39A8
Tbio
Family:  Transporter
Novelty:  0.00923197
Score:  0.637
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (41)
Basigin interactions (R-HSA-210991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
Basigin interactions
Cell surface interactions at the vascular wall
Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)
Disease
Disorders of transmembrane transporters
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
2
2
1
5.8
64.2
refractive error measurement
2
2
1
5.8
64.2
age at onset
1
1
0
5.8
28.1
age at onset
1
1
0
5.8
28.1
Myopia
1
1
0
5.8
28.1
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
1
5.8
64.2
refractive error measurement
1
5.8
64.2
age at onset
0
5.8
28.1
age at onset
0
5.8
28.1
Myopia
0
5.8
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 16 member 1
706593
Mouse
MGI:106013
20501
Rat
RGD:3690
25027
Dog
solute carrier family 16 member 1
VGNC:46235
475856
Horse
solute carrier family 16 member 1
VGNC:50886
100009694
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 16 member 1
Mouse
Rat
Dog
solute carrier family 16 member 1
Horse
solute carrier family 16 member 1
Publication Statistics
PubMed Score 337.33
PubMed score by year
PubTator Score 396.45
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title