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Tchem
PLA2G16
HRAS-like suppressor 3

Protein Summary
Description
Lipid-modifying enzyme that acts as major regulator of adipocyte lipolysis by catalyzing the release of fatty acids from phospholipids in adipose tissue (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616). Shows phospholipase A1 and A2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE) (PubMed:19615464, PubMed:19047760, PubMed:20837014, PubMed:22605381, PubMed:22923616). For most substrates, phospholipase A1 activity is much higher than phospholipase A2 activity (PubMed:19047760). Phospholipase activity causes decreased intracellular levels of ether-type lipids, affecting peroxisome metabolism (By similarity). May also have acyltransferase activity: catalyzes both N-acylation of phosphatidylethanolamine to form N-acyl-phosphatidylethanolamine and O-acylation of lyso-phosphatidylcholines to form phosphatidylcholines (PubMed:22605381, PubMed:25383759). The relevanc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323646
  • ENSP00000320337
  • ENSG00000176485
  • ENST00000415826
  • ENSP00000389124

Symbol
  • HRASLS3
  • HREV107
  • AdPLA
  • HRSL3
  • HRASLS3
  • HREV107
  • PLA2G16
  • PLAAT-3
  • H-REV107
  • HREV107-1
  • HREV107-3
  • H-REV107-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.93
transcription factor perturbation
0.88
virus perturbation
0.72
gene perturbation
0.71
small molecule perturbation
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.89   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 290   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.89   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 290   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (16)
Protein-Protein Interactions (92)
OCLN
Tbio
Novelty:  0.00047671
p_int:  0.998688483
p_ni:  0.001311514
p_wrong:  3e-9
Data Source:  BioPlex
MIB2
Tbio
Family:  Enzyme
Novelty:  0.044378
p_int:  0.997683964
p_ni:  0.002316031
p_wrong:  6e-9
Data Source:  BioPlex
CHPT1
Tbio
Family:  Enzyme
Novelty:  0.02875977
Score:  0.945
Data Source:  STRINGDB
CEPT1
Tchem
Family:  Enzyme
Novelty:  0.01816476
Score:  0.933
Data Source:  STRINGDB
PNPLA6
Tbio
Family:  Enzyme
Novelty:  0.00295195
Score:  0.92
Data Source:  STRINGDB
PLB1
Tbio
Family:  Enzyme
Novelty:  0.01628403
Score:  0.916
Data Source:  STRINGDB
LYPLA2
Tchem
Family:  Enzyme
Novelty:  0.05436006
Score:  0.912
Data Source:  STRINGDB
PNPLA7
Tdark
Family:  Enzyme
Novelty:  0.11025485
Score:  0.912
Data Source:  STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
Score:  0.91
Data Source:  STRINGDB
PLD1
Tchem
Family:  Enzyme
Novelty:  0.00608142
Score:  0.909
Data Source:  STRINGDB
Pathways (61)
Acyl chain remodelling of PC (R-HSA-1482788)

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Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PI
Reactome
Acyl chain remodelling of PS
Reactome
Glycerophospholipid biosynthesis
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PS
Glycerophospholipid biosynthesis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
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Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
1
1
53.2
urate measurement
1
1
2
49.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
uric acid measurement
1
53.2
urate measurement
2
49.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group XVI
VGNC:13391
451279
Macaque
phospholipase A2 group XVI
722178
Mouse
MGI:2179715
225845
Rat
RGD:2829
24913
Dog
phospholipase A2 group XVI
476045
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group XVI
Macaque
phospholipase A2 group XVI
Mouse
Rat
Dog
phospholipase A2 group XVI
Publication Statistics
PubMed Score 46.89
PubMed score by year
PubTator Score 25.16
PubTator score by year
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Related Publications
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PMID
Year
Title