Tbio RCAN1 Calcipressin-1

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Calcipressin-1

DTO Classes

Protein / Signaling / Calcipressin-1

Protein Summary

Description

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Uniprot Accession IDs

• P53805
• D3DSF9
• O00582
• O00583
• Q53XT0
• Q6IBC6
• Q7Z555
• Q96R03
• Q9BU69
• Q9UF15
• Q9UME4

Gene Name

• RCAN1

Ensembl ID

• ENST00000313806
• ENSP00000320768
• ENSG00000159200
• ENST00000381132
• ENSP00000370524
• ENST00000399272
• ENSP00000382214
• ENST00000443408
• ENSP00000392438
• ENST00000482533
• ENSP00000419624
• ENST00000487990
• ENSP00000419252
• ENST00000620920
• ENSP00000477646

Symbol

• ADAPT78
• CSP1
• DSC1
• DSCR1
• CSP1
• DSC1
• RCN1
• DSCR1
• MCIP1
• ADAPT78

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.9
transcription factor	0.9
PubMedID	0.89
transcription factor perturbation	0.88
disease perturbation	0.87

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.33   (req: < 5)

Gene RIFs: 86   (req: <= 3)

Antibodies: 521   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 280.33   (req: >= 5)

Gene RIFs: 86   (req: > 3)

Antibodies: 521   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (44)

KEGG (3)

PathwayCommons (3)

WikiPathways (38)

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Oxytocin signaling pathway	155 targets	path:hsa04921
KEGG	Kaposi sarcoma-associated herpesvirus infection	252 targets	path:hsa05167
KEGG	Thyroid hormone signaling pathway	119 targets	path:hsa04919

Name	Explore in Pharos	Explore in Source
Oxytocin signaling pathway	155 targets	path:hsa04921
Kaposi sarcoma-associated herpesvirus infection	252 targets	path:hsa05167
Thyroid hormone signaling pathway	119 targets	path:hsa04919

Gene Ontology Terms (12)

Functions (4)

Components (2)

Processes (6)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
calcium-dependent protein serine/threonine phosphatase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Traceable Author Statement (TAS)	ProtInc
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

PPP3CA

Tchem

Family: Enzyme

Novelty: 0.00238194

p_int: 1

Score: 0.954

Data Source: BioPlex,STRINGDB

PPP3CC

Tbio

Family: Enzyme

Novelty: 0.04180044

p_int: 1

Score: 0.827

Data Source: BioPlex,STRINGDB

PPP3R2

Tbio

Novelty: 0.0210854

p_int: 0.999999919

p_ni: 4.9e-8

p_wrong: 3.1e-8

Score: 0.368

Data Source: BioPlex,STRINGDB

GSK3A

Tclin

Family: Kinase

Novelty: 0.01538406

p_int: 0.99999773

p_ni: 7.7e-7

p_wrong: 0.000001501

Score: 0.715

Data Source: BioPlex,STRINGDB

PPP3CB

Tbio

Family: Enzyme

Novelty: 0.02520885

p_int: 0.999982418

p_ni: 0.000017582

Score: 0.846

Data Source: BioPlex,STRINGDB

PPP3R1

Tbio

Novelty: 0.00213192

p_int: 0.99997993

p_ni: 0.000020069

Score: 0.885

Data Source: BioPlex,STRINGDB

ARMT1

Tbio

Family: Enzyme

Novelty: 0.28301887

p_int: 0.999956051

p_ni: 0.000043949

Score: 0.269

Data Source: BioPlex,STRINGDB

SRBD1

Tbio

Novelty: 0.34233385

p_int: 0.999946791

p_ni: 0.000053205

p_wrong: 4e-9

Score: 0.694

Data Source: BioPlex,STRINGDB

FAM122A

Tbio

Novelty: 0.76767677

p_int: 0.999875073

p_ni: 0.000014226

p_wrong: 0.000110701

Score: 0.85

Data Source: BioPlex,STRINGDB

CST2

Tbio

Novelty: 0.03317401

p_int: 0.99884303

p_ni: 0.00079259

p_wrong: 0.00036438

Score: 0.186

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  280.33

PubMed score by year

Reset Zoom

PubTator Score  191.98

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEVDLQDLPSATIA

1-70

CHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYF

70-140

AQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPS

140-210

VVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS

210-252

MEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS

Find similar targets by:

Uniprot Keyword

Alternative splicing
Complete proteome
Phosphoprotein
Reference proteome