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Tbio
RCAN1
Calcipressin-1

Protein Summary
Description
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313806
  • ENSP00000320768
  • ENSG00000159200
  • ENST00000381132
  • ENSP00000370524
  • ENST00000399272
  • ENSP00000382214
  • ENST00000443408
  • ENSP00000392438
  • ENST00000482533
  • ENSP00000419624
  • ENST00000487990
  • ENSP00000419252
  • ENST00000620920
  • ENSP00000477646

Symbol
  • ADAPT78
  • CSP1
  • DSC1
  • DSCR1
  • CSP1
  • DSC1
  • RCN1
  • DSCR1
  • MCIP1
  • ADAPT78
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.9
transcription factor
0.9
PubMedID
0.89
transcription factor perturbation
0.88
disease perturbation
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.41   (req: < 5)
View Publications
Gene RIFs: 86   (req: <= 3)
View Gene RIFs
Antibodies: 521   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.41   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 521   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
regulator of calcineurin 1
697108
Mouse
regulator of calcineurin 1
MGI:1890564
54720
Rat
regulator of calcineurin 1
RGD:631338
266766
Dog
regulator of calcineurin 1
VGNC:45436
607887
Horse
regulator of calcineurin 1
VGNC:22262
100062432
Species
Name
OMA
EggNOG
Inparanoid
Macaque
regulator of calcineurin 1
Mouse
regulator of calcineurin 1
Rat
regulator of calcineurin 1
Dog
regulator of calcineurin 1
Horse
regulator of calcineurin 1
Pathways (44)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Oxytocin signaling pathway
155 targets
path:hsa04921
KEGG
Kaposi sarcoma-associated herpesvirus infection
252 targets
path:hsa05167
KEGG
Thyroid hormone signaling pathway
119 targets
path:hsa04919
Name
Explore in Pharos
Explore in Source
Oxytocin signaling pathway
155 targets
path:hsa04921
Kaposi sarcoma-associated herpesvirus infection
252 targets
path:hsa05167
Thyroid hormone signaling pathway
119 targets
path:hsa04919
Protein-Protein Interactions (83)
1 – 10 of 83
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00234189
p_int: 1
Score: 0.954
Data Source: BioPlex,STRINGDB
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 1
Score: 0.827
Data Source: BioPlex,STRINGDB
PPP3R2
Tbio
Novelty: 0.01121867
p_int: 0.999999919
p_ni: 4.9e-8
p_wrong: 3.1e-8
Score: 0.368
Data Source: BioPlex,STRINGDB
GSK3A
Tclin
Family: Kinase
Novelty: 0.00925708
p_int: 0.99999773
p_ni: 7.7e-7
p_wrong: 0.000001501
Score: 0.715
Data Source: BioPlex,STRINGDB
PPP3CB
Tbio
Family: Enzyme
Novelty: 0.02156713
p_int: 0.999982418
p_ni: 0.000017582
Score: 0.846
Data Source: BioPlex,STRINGDB
PPP3R1
Tbio
Novelty: 0.00263264
p_int: 0.99997993
p_ni: 0.000020069
Score: 0.885
Data Source: BioPlex,STRINGDB
ARMT1
Tbio
Family: Enzyme
Novelty: 0.19632869
p_int: 0.999956051
p_ni: 0.000043949
Score: 0.269
Data Source: BioPlex,STRINGDB
SRBD1
Tbio
Novelty: 0.18931356
p_int: 0.999946791
p_ni: 0.000053205
p_wrong: 4e-9
Score: 0.694
Data Source: BioPlex,STRINGDB
FAM122A
Tbio
Novelty: 0.3107759
p_int: 0.999875073
p_ni: 0.000014226
p_wrong: 0.000110701
Score: 0.85
Data Source: BioPlex,STRINGDB
CST2
Tbio
Novelty: 0.02114441
p_int: 0.99884303
p_ni: 0.00079259
p_wrong: 0.00036438
Score: 0.186
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  383.41

PubMed score by year
PubTator Score  191.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer