Tbio RCAN1 Calcipressin-1

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Calcipressin-1

DTO Classes

Protein / Signaling / Calcipressin-1

Protein Summary

Description

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

Uniprot Accession IDs

• P53805
• D3DSF9
• O00582
• O00583
• Q53XT0
• Q6IBC6
• Q7Z555
• Q96R03
• Q9BU69
• Q9UF15
• Q9UME4

Gene Name

• RCAN1

Ensembl ID

• ENST00000313806
• ENSP00000320768
• ENSG00000159200
• ENST00000381132
• ENSP00000370524
• ENST00000399272
• ENSP00000382214
• ENST00000443408
• ENSP00000392438
• ENST00000482533
• ENSP00000419624
• ENST00000487990
• ENSP00000419252
• ENST00000620920
• ENSP00000477646

Symbol

• ADAPT78
• CSP1
• DSC1
• DSCR1
• CSP1
• DSC1
• RCN1
• DSCR1
• MCIP1
• ADAPT78

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.9
transcription factor	0.9
PubMedID	0.89
transcription factor perturbation	0.88
disease perturbation	0.87

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.41   (req: < 5)

Gene RIFs: 86   (req: <= 3)

Antibodies: 521   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 383.41   (req: >= 5)

Gene RIFs: 86   (req: > 3)

Antibodies: 521   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	regulator of calcineurin 1		697108
Mouse	regulator of calcineurin 1	MGI:1890564	54720
Rat	regulator of calcineurin 1	RGD:631338	266766
Dog	regulator of calcineurin 1	VGNC:45436	607887
Horse	regulator of calcineurin 1	VGNC:22262	100062432

Species	Name	OMA	EggNOG	Inparanoid
Macaque	regulator of calcineurin 1
Mouse	regulator of calcineurin 1
Rat	regulator of calcineurin 1
Dog	regulator of calcineurin 1
Horse	regulator of calcineurin 1

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P53805-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (44)

KEGG (3)

PathwayCommons (3)

WikiPathways (38)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Oxytocin signaling pathway	155 targets	path:hsa04921
KEGG	Kaposi sarcoma-associated herpesvirus infection	252 targets	path:hsa05167
KEGG	Thyroid hormone signaling pathway	119 targets	path:hsa04919

Name	Explore in Pharos	Explore in Source
Oxytocin signaling pathway	155 targets	path:hsa04921
Kaposi sarcoma-associated herpesvirus infection	252 targets	path:hsa05167
Thyroid hormone signaling pathway	119 targets	path:hsa04919

Gene Ontology Terms (12)

Functions (4)

Components (2)

Processes (6)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
calcium-dependent protein serine/threonine phosphatase regulator activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA binding	Traceable Author Statement (TAS)	ProtInc
DNA-binding transcription factor activity	Traceable Author Statement (TAS)	ProtInc

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

PPP3CA

Tchem

Family: Enzyme

Novelty: 0.00234189

p_int: 1

Score: 0.954

Data Source: BioPlex,STRINGDB

PPP3CC

Tbio

Family: Enzyme

Novelty: 0.02633046

p_int: 1

Score: 0.827

Data Source: BioPlex,STRINGDB

PPP3R2

Tbio

Novelty: 0.01121867

p_int: 0.999999919

p_ni: 4.9e-8

p_wrong: 3.1e-8

Score: 0.368

Data Source: BioPlex,STRINGDB

GSK3A

Tclin

Family: Kinase

Novelty: 0.00925708

p_int: 0.99999773

p_ni: 7.7e-7

p_wrong: 0.000001501

Score: 0.715

Data Source: BioPlex,STRINGDB

PPP3CB

Tbio

Family: Enzyme

Novelty: 0.02156713

p_int: 0.999982418

p_ni: 0.000017582

Score: 0.846

Data Source: BioPlex,STRINGDB

PPP3R1

Tbio

Novelty: 0.00263264

p_int: 0.99997993

p_ni: 0.000020069

Score: 0.885

Data Source: BioPlex,STRINGDB

ARMT1

Tbio

Family: Enzyme

Novelty: 0.19632869

p_int: 0.999956051

p_ni: 0.000043949

Score: 0.269

Data Source: BioPlex,STRINGDB

SRBD1

Tbio

Novelty: 0.18931356

p_int: 0.999946791

p_ni: 0.000053205

p_wrong: 4e-9

Score: 0.694

Data Source: BioPlex,STRINGDB

FAM122A

Tbio

Novelty: 0.3107759

p_int: 0.999875073

p_ni: 0.000014226

p_wrong: 0.000110701

Score: 0.85

Data Source: BioPlex,STRINGDB

CST2

Tbio

Novelty: 0.02114441

p_int: 0.99884303

p_ni: 0.00079259

p_wrong: 0.00036438

Score: 0.186

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  383.41

PubMed score by year

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PubTator Score  191.98

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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MGI Phenotype Find Similar Targets

adipose tissue phenotype
cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
muscle phenotype
neoplasm