TTC3
E3 ubiquitin-protein ligase TTC3
Protein Summary
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT.
- ENST00000354749
- ENSP00000346791
- ENSG00000182670
- ENST00000355666
- ENSP00000347889
- ENST00000399017
- ENSP00000381981
- DCRR1
- RNF105
- TPRD
- DCRR1
- RNF105
- TPRDIII
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
transcription factor perturbation | 1 | ||
virus perturbation | 0.92 | ||
disease perturbation | 0.9 | ||
histone modification site profile | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.52 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 68 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 40.52 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 68 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0