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Tbio
POLR2K
DNA-directed RNA polymerases I, II, and III subunit RPABC4

Protein Summary
Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353107
  • ENSP00000342889
  • ENSG00000147669

Symbol
  • RPB12
  • RPABC4
  • RPB7.0
  • hRPB7.0
  • hsRPB10a
  • RPB10alpha
  • ABC10-alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.97
virus perturbation
0.9
biological process
0.88
histone modification site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.8   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.8   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (581)
1 – 10 of 581
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.976925163
p_ni:  0.013053282
p_wrong:  0.010021555
Score:  0.999
Data Source:  BioPlex,STRINGDB
POLR2L
Tbio
Family:  Enzyme
Novelty:  0.03847579
Score:  0.999
Data Source:  STRINGDB
POLR2A
Tbio
Family:  Enzyme
Novelty:  0.00188323
Score:  0.999
Data Source:  STRINGDB
POLR2B
Tbio
Family:  Enzyme
Novelty:  0.0012624
Score:  0.999
Data Source:  STRINGDB
POLR2E
Tbio
Family:  Enzyme
Novelty:  0.01817288
Score:  0.999
Data Source:  STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
Score:  0.999
Data Source:  STRINGDB
POLR2C
Tbio
Family:  Enzyme
Novelty:  0.01652813
Score:  0.999
Data Source:  STRINGDB
POLR2H
Tbio
Family:  Enzyme
Novelty:  0.04008409
Score:  0.999
Data Source:  STRINGDB
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
Score:  0.999
Data Source:  STRINGDB
POLR2I
Tbio
Family:  Enzyme
Novelty:  0.03100605
Score:  0.999
Data Source:  STRINGDB
Pathways (98)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 91
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Cytosolic sensors of pathogen-associated DNA
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
B-WICH complex positively regulates rRNA expression
Cytosolic sensors of pathogen-associated DNA
Gene Ontology Terms (24)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
6.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit K
VGNC:10221
741257
Mouse
MGI:102725
17749
Rat
RGD:2319895
100361574
Dog
RNA polymerase II subunit K
VGNC:44799
100688583
Horse
RNA polymerase II subunit K
VGNC:21682
100630612
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA polymerase II subunit K
Mouse
Rat
Dog
RNA polymerase II subunit K
Horse
RNA polymerase II subunit K
Publication Statistics
PubMed Score 11.80
PubMed score by year
PubTator Score 3.86
PubTator score by year