Tbio PTTG1IP Pituitary tumor-transforming gene 1 protein-interacting protein

Protein Summary

Description

May facilitate PTTG1 nuclear translocation. This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]

Uniprot Accession IDs

• P53801
• B2RDP7
• D3DSL9
• Q9NS09

Gene Name

• PTTG1IP

Ensembl ID

• ENST00000330938
• ENSP00000328325
• ENSG00000183255

Symbol

• C21orf1
• C21orf3
• PBF
• C21orf1
• C21orf3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
disease perturbation	0.97
transcription factor perturbation	0.96
transcription factor binding site profile	0.85
virus perturbation	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.32   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.32   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0