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Tchem
MAPK12
Mitogen-activated protein kinase 12

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215659
  • ENSP00000215659
  • ENSG00000188130
  • ENST00000622558
  • ENSP00000479972

Symbol
  • ERK6
  • SAPK3
  • ERK3
  • ERK6
  • ERK-6
  • SAPK3
  • PRKM12
  • SAPK-3
  • MAPK 12
  • P38GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
kinase perturbation
0.88
protein domain
0.85
biological process
0.84
PubMedID
0.76


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.2   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 496   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.2   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 496   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 12
VGNC:12897
747077
Macaque
mitogen-activated protein kinase 12
715745
Mouse
MGI:1353438
29857
Rat
RGD:70975
60352
Dog
mitogen-activated protein kinase 12
VGNC:42993
607023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 12
Macaque
mitogen-activated protein kinase 12
Mouse
Rat
Dog
mitogen-activated protein kinase 12
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P53778-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (123)
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (R-HSA-2151209)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Axon guidance
Reactome
DSCAM interactions
Reactome
Developmental Biology
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Axon guidance
DSCAM interactions
Developmental Biology
Immune System
Protein-Protein Interactions (232)
1 – 10 of 232
MAPK13
Tchem
Family: Kinase
Novelty: 0.01071621
p_int: 0.999989179
p_ni: 1e-9
p_wrong: 0.00001082
Score: 0.948
Data Source: BioPlex,STRINGDB
MYLK3
Tchem
Family: Kinase
Novelty: 0.00661904
p_int: 0.998311096
p_ni: 0.001661757
p_wrong: 0.000027147
Score: 0.538
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.996637874
p_ni: 0.003356758
p_wrong: 0.000005368
Data Source: BioPlex
PARP11
Tbio
Family: Enzyme
Novelty: 0.11901686
p_int: 0.996635725
p_ni: 0.003364097
p_wrong: 1.78e-7
Score: 0.622
Data Source: BioPlex,STRINGDB
SPANXN4
Tdark
Novelty: 1.91062423
p_int: 0.910520551
p_ni: 0.08759826
p_wrong: 0.00188119
Data Source: BioPlex
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.977
Data Source: STRINGDB
MAP2K3
Tchem
Family: Kinase
Novelty: 0.00349605
Score: 0.975
Data Source: STRINGDB
SNTA1
Tbio
Novelty: 0.01668288
Score: 0.972
Data Source: STRINGDB
MAPKAPK3
Tchem
Family: Kinase
Novelty: 0.02469147
Score: 0.969
Data Source: STRINGDB
MAPKAPK2
Tchem
Family: Kinase
Novelty: 0.00486452
Score: 0.968
Data Source: STRINGDB
Publication Statistics
PubMed Score  112.20

PubMed score by year
PubTator Score  59.54

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer