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Tbio
ITGA8
Integrin alpha-8

Protein Summary
Description
Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378076
  • ENSP00000367316
  • ENSG00000077943
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.86
biological process
0.73
protein domain
0.73
virus perturbation
0.72
gene perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.13   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.13   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
34.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
34.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 8
VGNC:12349
450323
Macaque
integrin subunit alpha 8
698888
Mouse
MGI:109442
241226
Rat
RGD:621634
364786
Dog
integrin subunit alpha 8
VGNC:42130
487119
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha 8
Macaque
integrin subunit alpha 8
Mouse
Rat
Dog
integrin subunit alpha 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P53708-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Integrin cell surface interactions
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Elastic fibre formation
Extracellular matrix organization
Integrin cell surface interactions
Molecules associated with elastic fibres
Gene Ontology Terms (27)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (137)
1 – 10 of 137
SUSD4
Tbio
Novelty: 0.22201938
p_int: 0.999557171
p_ni: 0.000442678
p_wrong: 1.5e-7
Data Source: BioPlex
BTNL8
Tdark
Novelty: 0.40339869
p_int: 0.998723122
p_ni: 0.001276877
p_wrong: 1e-9
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.998541494
p_ni: 0.001458506
Data Source: BioPlex
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.997808871
p_ni: 0.002191111
p_wrong: 1.8e-8
Data Source: BioPlex
DKKL1
Tbio
Novelty: 0.00544618
p_int: 0.997492574
p_ni: 0.002507236
p_wrong: 1.9e-7
Data Source: BioPlex
CLU
Tbio
Novelty: 0.00054776
p_int: 0.997451574
p_ni: 0.00254841
p_wrong: 1.6e-8
Data Source: BioPlex
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
p_int: 0.997003637
p_ni: 0.002996324
p_wrong: 4e-8
Score: 0.206
Data Source: BioPlex,STRINGDB
ADAM18
Tdark
Family: Enzyme
Novelty: 0.22622379
p_int: 0.988775564
p_ni: 0.011224354
p_wrong: 8.2e-8
Data Source: BioPlex
BST1
Tbio
Family: Enzyme
Novelty: 0.01329061
p_int: 0.984758111
p_ni: 0.015241885
p_wrong: 3e-9
Data Source: BioPlex
PNLIPRP1
Tbio
Family: Enzyme
Novelty: 0.04756238
p_int: 0.975402814
p_ni: 0.024153881
p_wrong: 0.000443305
Data Source: BioPlex
Publication Statistics
PubMed Score  44.13

PubMed score by year
PubTator Score  15.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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