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Tbio
HCCS
Cytochrome c-type heme lyase

Protein Classes
Protein Summary
Description
Links covalently the heme group to the apoprotein of cytochrome c. The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321143
  • ENSP00000326579
  • ENSG00000004961
  • ENST00000380762
  • ENSP00000370139
  • ENST00000380763
  • ENSP00000370140

Symbol
  • CCHL
  • MLS
  • CCHL
  • MCOPS7
  • LSDMCA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor perturbation
0.91
co-expressed gene
0.87
disease perturbation
0.87
histone modification site profile
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.49   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.49   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
holocytochrome c synthase
VGNC:12393
465489
Macaque
cytochrome c-type heme lyase
709878
Mouse
MGI:106911
15159
Rat
RGD:1563855
317444
Dog
holocytochrome c synthase
VGNC:41614
480834
Species
Name
OMA
EggNOG
Inparanoid
Chimp
holocytochrome c synthase
Macaque
cytochrome c-type heme lyase
Mouse
Rat
Dog
holocytochrome c synthase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P53701-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (128)
1 – 10 of 128
NPAT
Tbio
Novelty: 0.01063979
p_int: 0.999999379
p_ni: 6.21e-7
Score: 0.353
Data Source: BioPlex,STRINGDB
PHF23
Tbio
Family: Epigenetic
Novelty: 0.17699844
p_int: 0.999991559
p_ni: 0.00000844
Score: 0.252
Data Source: BioPlex,STRINGDB
CHCHD5
Tbio
Novelty: 0.16304141
p_int: 0.999905783
p_ni: 0.000094217
Data Source: BioPlex
CYC1
Tbio
Novelty: 0.01369865
p_int: 0.999895592
p_ni: 0.000104408
Score: 0.813
Data Source: BioPlex,STRINGDB
AGK
Tbio
Family: Enzyme
Novelty: 0.00919083
p_int: 0.999893966
p_ni: 0.000106034
Score: 0.181
Data Source: BioPlex,STRINGDB
FZR1
Tbio
Novelty: 0.01599606
p_int: 0.999854154
p_ni: 0.000145846
Data Source: BioPlex
SNX20
Tdark
Novelty: 0.28934317
p_int: 0.999489178
p_ni: 0.000510392
p_wrong: 4.3e-7
Data Source: BioPlex
METTL16
Tbio
Family: Enzyme
Novelty: 0.07771662
p_int: 0.998922161
p_ni: 0.000005253
p_wrong: 0.001072586
Score: 0.272
Data Source: BioPlex,STRINGDB
MRRF
Tbio
Novelty: 0.00269663
p_int: 0.997429145
p_ni: 0.002570855
Score: 0.253
Data Source: BioPlex,STRINGDB
GRPR
Tchem
Family: GPCR
Novelty: 0.00282511
p_int: 0.994393474
p_ni: 0.005606521
p_wrong: 5e-9
Score: 0.48
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  455.49

PubMed score by year
PubTator Score  453.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer