Tbio CLTCL1 Clathrin heavy chain 2

Protein Summary

Description

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity). This gene is a member of the clathrin heavy chain family and encodes a major protein of the polyhedral coat of coated pits and vesicles. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Uniprot Accession IDs

• P53675
• B7Z7U5
• Q14017
• Q15808
• Q15809

Gene Name

• CLTCL1

Ensembl ID

• ENST00000427926
• ENSP00000441158
• ENSG00000070371
• ENST00000621271
• ENSP00000485020

Symbol

• CLH22
• CLTCL
• CLTD
• CLTD
• CHC22
• CLH22
• CLTCL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.97
protein domain	0.97
cell type or tissue	0.91
protein complex	0.83
cell line	0.68

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Clathrin Heavy Chain 2

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Clathrin Heavy Chain 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.7   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 67   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.7   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (313)

Explore Interacting Targets

1 – 10 of 313

• See Interactions on String-DB

STAMBPL1

Tbio

Family:  Enzyme

Novelty:  0.08532786

p_int:  0.999998363

p_ni:  0.000001637

Score:  0.33

Data Source:  BioPlex,STRINGDB

STAMBP

Tchem

Novelty:  0.01543821

p_int:  0.999997933

p_ni:  0.000002067

Score:  0.238

Data Source:  BioPlex,STRINGDB

CLINT1

Tbio

Novelty:  0.00945381

p_int:  0.999994882

p_ni:  0.000005118

Score:  0.517

Data Source:  BioPlex,STRINGDB

PICALM

Tbio

Novelty:  0.00800832

p_int:  0.999982724

p_ni:  0.000017276

Score:  0.983

Data Source:  BioPlex,STRINGDB

HSPBP1

Tbio

Novelty:  0.01176285

p_int:  0.99983254

p_ni:  0.00016746

Score:  0.197

Data Source:  BioPlex,STRINGDB

OR13A1

Tdark

Family:  oGPCR

Novelty:  8.09174312

p_int:  0.998766559

p_ni:  0.001233441

Data Source:  BioPlex

CCL21

Tbio

Novelty:  0.00130736

p_int:  0.998542021

p_ni:  0.001457979

Score:  0.178

Data Source:  BioPlex,STRINGDB

CCDC27

Tdark

Novelty:  1.27912281

p_int:  0.998393667

p_ni:  0.001606333

Score:  0.177

Data Source:  BioPlex,STRINGDB

PTP4A1

Tchem

Family:  Enzyme

Novelty:  0.02863007

p_int:  0.998165768

p_ni:  0.001834232

Data Source:  BioPlex

CUTA

Tbio

Novelty:  0.01771609

p_int:  0.997784224

p_ni:  0.002215776

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (24)

Reactome (12)

KEGG (6)

PathwayCommons (2)

WikiPathways (4)

Axon guidance (R-HSA-422475)

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1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (23)

Functions (2)

Components (13)

Processes (8)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
clathrin light chain binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
structural molecule activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
citrate measurement	EFO_0010114	2	3	3		87.9
blood metabolite measurement	EFO_0005664	1	1	1		52
amino acid measurement	EFO_0005134	1	1	1		52
protein measurement	EFO_0004747	1	1	1		52
metabolite measurement	EFO_0004725	1	1	1		44.4

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
citrate measurement	EFO_0010114	3		87.9
blood metabolite measurement	EFO_0005664	1		52
amino acid measurement	EFO_0005134	1		52
protein measurement	EFO_0004747	1		52
metabolite measurement	EFO_0004725	1		44.4

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Alternative splicing
Coated pit
Complete proteome
Cytoplasmic vesicle
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
alanine measurement
amino acid measurement
blood metabolite measurement
citrate measurement
glomerular filtration rate
metabolite measurement
protein measurement
serum metabolite measurement

IDG Resources

No IDG generated resources found

Orthologs (5)

1 – 5 of 5

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	clathrin heavy chain like 1		719087
Dog	clathrin heavy chain like 1	VGNC:39368	477568
Opossum	clathrin heavy chain like 1		100029287
C. elegans	Probable clathrin heavy chain 1		176434
S.cerevisiae	clathrin heavy chain	S000003174	852666

Species	Name	OMA	EggNOG	Inparanoid
Macaque	clathrin heavy chain like 1
Dog	clathrin heavy chain like 1
Opossum	clathrin heavy chain like 1
C. elegans	Probable clathrin heavy chain 1
S.cerevisiae	clathrin heavy chain

Publication Statistics

PubMed Score 25.70

PubMed score by year

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PubTator Score 17.63

PubTator score by year

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Related Publications

Text Mined References (29)

GeneRif Annotations (10)

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10

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PMID	Year	Title