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Tdark
CRYBA2
Beta-crystallin A2

Protein Summary
Description
Crystallins are the dominant structural components of the vertebrate eye lens. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of the vertebrate eye, which function to maintain the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also defined as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group but absent in the acidic group). Beta-crystallins form ag ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295728
  • ENSP00000295728
  • ENSG00000163499
  • ENST00000392096
  • ENSP00000375946

Symbol
  • CTRCT42
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.77
virus perturbation
0.76
PubMedID
0.54
transcription factor
0.5
cell line
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.23   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.23   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (30)
1 – 10 of 30
CRYAA
Tbio
Novelty: 0.03207592
Score: 0.788
Data Source: STRINGDB
CRYAA2
Tdark
Novelty: 0.03207592
Score: 0.788
Data Source: STRINGDB
CFAP65
Tdark
Novelty: 0.43298969
Score: 0.735
Data Source: STRINGDB
CRYAB
Tbio
Novelty: 0.00547363
Score: 0.662
Data Source: STRINGDB
KRBA1
Tdark
Novelty: 3.75
Score: 0.556
Data Source: STRINGDB
LIM2
Tbio
Novelty: 0.01713049
Score: 0.527
Data Source: STRINGDB
TM4SF4
Tbio
Novelty: 0.13095671
Score: 0.511
Data Source: STRINGDB
MUC13
Tbio
Novelty: 0.01261341
Score: 0.507
Data Source: STRINGDB
GABRG2
Tclin
Family: IC
Novelty: 0.01062612
Score: 0.505
Data Source: STRINGDB
C1QTNF12
Tbio
Novelty: 0.09725975
Score: 0.502
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.23

PubMed score by year
PubTator Score  3.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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