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Tchem
LIMK2
LIM domain kinase 2

Protein Summary
Description
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331728
  • ENSP00000332687
  • ENSG00000182541
  • ENST00000333611
  • ENSP00000330470
  • ENST00000340552
  • ENSP00000339916
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
transcription factor perturbation
0.96
kinase perturbation
0.91
transcription factor
0.91
transcription factor binding site profile
0.86


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.43   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 525   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.43   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 525   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 103
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (103)
1 – 10 of 103
compound 30 [PMID: 22902653]
Rendered image for compound 30 [PMID: 22902653]
CHEMBL2070615
Rendered image for CHEMBL2070615
CHEMBL2070619
Rendered image for CHEMBL2070619
CHEMBL1258976
Rendered image for CHEMBL1258976
CHEMBL3613621
Rendered image for CHEMBL3613621
CHEMBL3613610
Rendered image for CHEMBL3613610
CHEMBL3356433
Rendered image for CHEMBL3356433
CHEMBL3613620
Rendered image for CHEMBL3613620
CHEMBL3613600
Rendered image for CHEMBL3613600
CHEMBL570126
Rendered image for CHEMBL570126
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
92.5
eosinophil percentage of leukocytes
2
2
2
91.4
red blood cell distribution width
3
3
3
78.1
eosinophil percentage of granulocytes
1
1
1
68.6
reticulocyte count
3
1
3
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
92.5
eosinophil percentage of leukocytes
2
91.4
red blood cell distribution width
3
78.1
eosinophil percentage of granulocytes
1
68.6
reticulocyte count
3
63.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM domain kinase 2
VGNC:53399
458970
Macaque
LIM domain kinase 2
716614
Mouse
MGI:1197517
16886
Rat
RGD:62056
29524
Dog
LIM domain kinase 2
VGNC:52937
486363
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM domain kinase 2
Macaque
LIM domain kinase 2
Mouse
Rat
Dog
LIM domain kinase 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P53671-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Reactome
RHO GTPase Effectors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
RHO GTPase Effectors
Protein-Protein Interactions (56)
1 – 10 of 56
UNC119
Tchem
Novelty:  0.00396292
p_int:  0.999999974
p_ni:  2.6e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
SFTPA2
Tbio
Novelty:  0.00283745
p_int:  0.999999033
p_ni:  9.67e-7
Data Source:  BioPlex
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.999876127
p_ni:  0.000123873
Data Source:  BioPlex
TTC1
Tbio
Novelty:  0.01389711
p_int:  0.998995247
p_ni:  0.001004753
Score:  0.187
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.979518773
p_ni:  0.020481227
Score:  0.165
Data Source:  BioPlex,STRINGDB
SLC18A1
Tchem
Family:  Transporter
Novelty:  0.01135292
p_int:  0.929132042
p_ni:  0.002316308
p_wrong:  0.06855165
Data Source:  BioPlex
TRIM35
Tbio
Novelty:  0.03280419
p_int:  0.833941311
p_ni:  0.001275066
p_wrong:  0.164783624
Score:  0.18
Data Source:  BioPlex,STRINGDB
CFL1
Tbio
Novelty:  0.00071544
Score:  0.991
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.967
Data Source:  STRINGDB
ROCK1
Tclin
Family:  Kinase
Novelty:  0.00156045
Score:  0.964
Data Source:  STRINGDB
Publication Statistics
PubMed Score  62.43

PubMed score by year
PubTator Score  44.22

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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