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Tchem
LIMK1
LIM domain kinase 1

Protein Summary
Description
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336180
  • ENSP00000336740
  • ENSG00000106683
  • ENST00000435201
  • ENSP00000414606
  • ENST00000538333
  • ENSP00000444452

Symbol
  • LIMK
  • LIMK
  • LIMK-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
biological process
0.91
kinase
0.86
protein domain
0.85
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.83   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 887   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.83   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 887   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 61
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1