Protein Summary
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphor ...more
- ENST00000336180
- ENSP00000336740
- ENSG00000106683
- ENST00000435201
- ENSP00000414606
- ENST00000538333
- ENSP00000444452
- LIMK
- LIMK
- LIMK-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.98 | ||
biological process | 0.91 | ||
kinase | 0.86 | ||
protein domain | 0.85 | ||
transcription factor perturbation | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 303.23 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 887 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 303.23 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 887 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 61
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (61)
Protein-Protein Interactions (141)
Nearest Tclin Targets (2)
Upstream (2)
1 – 2 of 2
Pathways (37)
Reactome (17)
KEGG (5)
PathwayCommons (7)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPHB-mediated forward signaling | ||||
Reactome | Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPHB-mediated forward signaling | ||||
Fcgamma receptor (FCGR) dependent phagocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (6)
Components (8)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte count | 1 | 1 | 1 | 45.2 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 40.7 | |||||
2 | 2 | 0 | 1.6 | 32.8 | |||||
pulse pressure measurement | 1 | 1 | 1 | 8.9 | |||||
1 | 1 | 0 | 1.5 | 7.1 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte count | 1 | 45.2 | |||||
serum non-albumin protein measurement | 1 | 40.7 | |||||
0 | 1.6 | 32.8 | |||||
pulse pressure measurement | 1 | 8.9 | |||||
0 | 1.5 | 7.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | LIM domain kinase 1 | VGNC:14036 | 463466 | |||||
Macaque | LIM domain kinase 1 | 699494 | ||||||
Mouse | MGI:104572 | 16885 | ||||||
Rat | RGD:62055 | 65172 | ||||||
Dog | LIM domain kinase 1 | VGNC:42681 | 489800 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | LIM domain kinase 1 | |||||
Macaque | LIM domain kinase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | LIM domain kinase 1 | |||||
Publication Statistics
PubMed Score 303.23
PubMed score by year
PubTator Score 170.13
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (114)
GeneRif Annotations (77)
Items per page:
0 of 0
PMID | Year | Title |
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