Tchem CTSC Dipeptidyl peptidase 1

Protein Summary

Description

Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P53634
• A8K7V2
• B5MDD5
• Q2HIY8
• Q53G93
• Q71E75
• Q71E76
• Q7M4N9
• Q7Z3G7
• Q7Z5U7
• Q8WY99
• Q8WYA7
• Q8WYA8

Gene Name

• CTSC

Ensembl ID

• ENST00000227266
• ENSP00000227266
• ENSG00000109861
• ENST00000524463
• ENSP00000432541
• ENST00000529974
• ENSP00000433539

Symbol

• CPPI
• JP
• HMS
• JPD
• PLS
• CPPI
• DPP1
• DPPI
• PALS
• DPP-I
• PDON1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
virus perturbation	1
disease perturbation	0.96
kinase perturbation	0.95
PubMedID	0.92

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Cysteine Protease / Dipeptidyl Peptidase 1

Protein / ... / Protease Inhibitor / Dipeptidyl Peptidase 1

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Dipeptidyl Peptidase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1103.14   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1103.14   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 745

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0