Protein Summary
Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B. Can also activate neuraminidase and factor XIII. This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride i ...more
- ENST00000227266
- ENSP00000227266
- ENSG00000109861
- ENST00000524463
- ENSP00000432541
- ENST00000529974
- ENSP00000433539
- CPPI
- JP
- HMS
- JPD
- PLS
- CPPI
- DPP1
- DPPI
- PALS
- DPP-I
- PDON1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
virus perturbation | 1 | ||
disease perturbation | 0.96 | ||
kinase perturbation | 0.95 | ||
PubMedID | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.15 (req: < 5)
Gene RIFs: 44 (req: <= 3)
Antibodies: 257 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 862.15 (req: >= 5)
Gene RIFs: 44 (req: > 3)
Antibodies: 257 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 697
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (697)
Protein-Protein Interactions (246)
WFDC9
Novelty: 3.44827586
p_int: 0.994723877
p_ni: 0.005276123
Score: 0.68
Data Source: BioPlex,STRINGDB
CSTA
Novelty: 0.00453121
p_int: 0.993962125
p_ni: 0.006037875
Score: 0.376
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (16)
Reactome (14)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | COPII-mediated vesicle transport | ||||
Reactome | Cargo concentration in the ER | ||||
Reactome | ER to Golgi Anterograde Transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Asparagine N-linked glycosylation | ||||
COPII-mediated vesicle transport | ||||
Cargo concentration in the ER | ||||
ER to Golgi Anterograde Transport | ||||
Viral Interactions (0)
Gene Ontology Terms (34)
Functions (9)
Components (14)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
basophil percentage of leukocytes | 1 | 1 | 1 | 42.3 | |||||
self reported educational attainment | 1 | 1 | 1 | 38.2 | |||||
gut microbiome measurement | 1 | 1 | 0 | 6 | 33.1 | ||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
basophil percentage of leukocytes | 1 | 42.3 | |||||
self reported educational attainment | 1 | 38.2 | |||||
gut microbiome measurement | 0 | 6 | 33.1 | ||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cathepsin C | VGNC:3140 | 451469 | |||||
Macaque | cathepsin C | 705320 | ||||||
Mouse | MGI:109553 | 13032 | ||||||
Rat | RGD:2445 | 25423 | ||||||
Dog | cathepsin C | 403458 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cathepsin C | |||||
Macaque | cathepsin C | |||||
Mouse | ||||||
Rat | ||||||
Dog | cathepsin C | |||||
Publication Statistics
PubMed Score 862.15
PubMed score by year
PubTator Score 307.64
PubTator score by year
Related Publications
Text Mined References (87)
GeneRif Annotations (44)
Items per page:
0 of 0
PMID | Year | Title |
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