You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
RABGGTB
Geranylgeranyl transferase type-2 subunit beta

Protein Summary
Description
Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319942
  • ENSP00000317473
  • ENSG00000137955

Symbol
  • GGTB
  • GGTB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
disease perturbation
0.83
molecular function
0.7
transcription factor binding site profile
0.69
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.78   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.78   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
4
80.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
4
80.7
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rab geranylgeranyltransferase subunit beta
VGNC:6972
100614714
Macaque
Rab geranylgeranyltransferase beta subunit
705421
Mouse
MGI:99537
19352
Rat
RGD:3530
25533
Dog
Rab geranylgeranyltransferase subunit beta
VGNC:45304
612683
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rab geranylgeranyltransferase subunit beta
Macaque
Rab geranylgeranyltransferase beta subunit
Mouse
Rat
Dog
Rab geranylgeranyltransferase subunit beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P53611-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (142)
1 – 10 of 142
PTAR1
Tdark
Family: Enzyme
Novelty: 0.37120559
p_int: 0.999999996
p_ni: 1e-9
p_wrong: 3e-9
Score: 0.705
Data Source: BioPlex,STRINGDB
RABGGTA
Tdark
Family: Enzyme
Novelty: 0.19962321
p_int: 0.999999994
p_ni: 6e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PGBD5
Tdark
Novelty: 0.15960609
p_int: 0.999999991
p_ni: 1e-9
p_wrong: 8e-9
Score: 0.23
Data Source: BioPlex,STRINGDB
RAB40B
Tbio
Novelty: 0.2288213
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.937
Data Source: BioPlex,STRINGDB
PXN
Tbio
Novelty: 0.00082031
p_int: 0.999999662
p_ni: 3.37e-7
Score: 0.173
Data Source: BioPlex,STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
p_int: 0.999998645
p_ni: 0.000001354
p_wrong: 1e-9
Data Source: BioPlex
PIP5K1C
Tchem
Family: Kinase
Novelty: 0.0323077
p_int: 0.999995354
p_ni: 1.5e-8
p_wrong: 0.000004631
Score: 0.66
Data Source: BioPlex,STRINGDB
PIP5K1A
Tbio
Family: Kinase
Novelty: 0.05039085
p_int: 0.999995006
p_ni: 0.000004993
p_wrong: 1e-9
Data Source: BioPlex
PPP1R16A
Tdark
Family: Enzyme
Novelty: 0.1958289
p_int: 0.999992673
p_ni: 1.3e-8
p_wrong: 0.000007314
Score: 0.23
Data Source: BioPlex,STRINGDB
INPP5A
Tchem
Family: Enzyme
Novelty: 0.03249263
p_int: 0.999983032
p_ni: 0.000016967
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  13.78

PubMed score by year
PubTator Score  4.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer