Tchem MVD Diphosphomevalonate decarboxylase

Protein Summary

Description

Performs the first committed step in the biosynthesis of isoprenes. The enzyme mevalonate pyrophosphate decarboxylase catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P53602
• Q53Y65

Gene Name

• MVD

Ensembl ID

• ENST00000301012
• ENSP00000301012
• ENSG00000167508

Symbol

• MPD
• MPD
• MDDase
• POROK7
• FP17780

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
histone modification site profile	0.91
protein domain	0.85
gene perturbation	0.71
cell line	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.79   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 180   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 203.79   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0