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Tchem
METAP1
Methionine aminopeptidase 1

Protein Summary
Description
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296411
  • ENSP00000296411
  • ENSG00000164024

Symbol
  • KIAA0094
  • MAP1A
  • MetAP1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.98
kinase perturbation
0.95
virus perturbation
0.92
histone modification site profile
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.42   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.42   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 66
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
1
1
79.2
alcohol use disorder measurement
1
1
0
10.5
78.9
alcohol dependence measurement
1
1
1
53.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
1
79.2
alcohol use disorder measurement
0
10.5
78.9
alcohol dependence measurement
1
53.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methionyl aminopeptidase 1
VGNC:48918
461392
Macaque
methionyl aminopeptidase 1
710537
Mouse
MGI:1922874
75624
Rat
RGD:1305545
295500
Dog
methionyl aminopeptidase 1
VGNC:43167
487871
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methionyl aminopeptidase 1
Macaque
methionyl aminopeptidase 1
Mouse
Rat
Dog
methionyl aminopeptidase 1
Protein Data Bank (30)
1 – 5 of 30
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Protein-Protein Interactions (119)
1 – 10 of 119
CBWD1
Tbio
Novelty: 0.04321511
p_int: 0.999999907
p_ni: 9.3e-8
Score: 0.473
Data Source: BioPlex,STRINGDB
GH2
Tbio
Novelty: 0.00071871
p_int: 0.999953556
p_ni: 0.000046444
Score: 0.517
Data Source: BioPlex,STRINGDB
CBWD2
Tdark
Novelty: 5.35433071
p_int: 0.999934831
p_ni: 0.000065169
Score: 0.866
Data Source: BioPlex,STRINGDB
BTF3
Tbio
Novelty: 0.01198537
p_int: 0.998742335
p_ni: 0.001257665
Data Source: BioPlex
NAA40
Tbio
Family: Enzyme
Novelty: 0.13882523
p_int: 0.995221894
p_ni: 0.004778106
Score: 0.648
Data Source: BioPlex,STRINGDB
NPPA
Tchem
Novelty: 0.00046693
p_int: 0.988841062
p_ni: 0.011158903
p_wrong: 3.5e-8
Data Source: BioPlex
PLPPR2
Tdark
Family: Enzyme
Novelty: 1.03318406
p_int: 0.983109264
p_ni: 0.016890736
Score: 0.161
Data Source: BioPlex,STRINGDB
TCL1A
Tbio
Novelty: 0.00606987
p_int: 0.96398099
p_ni: 0.035996046
p_wrong: 0.000022965
Data Source: BioPlex
MRPS12
Tbio
Novelty: 0.15394123
p_int: 0.842439283
p_ni: 0.157560071
p_wrong: 6.47e-7
Data Source: BioPlex
CCL3L1
Tbio
Novelty: 0.01124082
p_int: 0.824225685
p_ni: 0.17500236
p_wrong: 0.000771955
Data Source: BioPlex
Publication Statistics
PubMed Score  50.42

PubMed score by year
PubTator Score  23.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer