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Tbio
CEBPG
CCAAT/enhancer-binding protein gamma

Protein Summary
Description
Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter. The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284000
  • ENSP00000284000
  • ENSG00000153879
  • ENST00000585933
  • ENSP00000466022

Symbol
  • GPE1BP
  • IG/EBP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
transcription factor perturbation
0.94
disease perturbation
0.93
biological process
0.86
microRNA
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.6   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.6   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (87)
1 – 10 of 87
CREB5
Tbio
Family:  TF
Novelty:  0.03857106
p_int:  0.999999738
p_ni:  2.62e-7
Data Source:  BioPlex
ATF7
Tbio
Family:  TF
Novelty:  0.01470313
p_int:  0.99999924
p_ni:  7.59e-7
p_wrong:  2e-9
Score:  0.416
Data Source:  BioPlex,STRINGDB
NUCB2
Tbio
Novelty:  0.00831106
p_int:  0.999996006
p_ni:  0.000003994
Data Source:  BioPlex
CCDC106
Tdark
Novelty:  0.7081207
p_int:  0.99997769
p_ni:  0.000022306
p_wrong:  4e-9
Data Source:  BioPlex
ATF2
Tbio
Family:  TF
Novelty:  0.00457832
p_int:  0.9998886
p_ni:  0.0001114
p_wrong:  1e-9
Score:  0.434
Data Source:  BioPlex,STRINGDB
CCDC85B
Tdark
Novelty:  0.02034018
p_int:  0.999662015
p_ni:  0.000152096
p_wrong:  0.000185888
Data Source:  BioPlex
KIF5A
Tbio
Novelty:  0.01277095
p_int:  0.999660844
p_ni:  0.000339156
Data Source:  BioPlex
JUND
Tbio
Family:  TF
Novelty:  0.00277701
p_int:  0.99963323
p_ni:  0.000250371
p_wrong:  0.000116398
Score:  0.348
Data Source:  BioPlex,STRINGDB
TEDC1
Tdark
Novelty:  0.74182963
p_int:  0.99832716
p_ni:  0.001669705
p_wrong:  0.000003136
Data Source:  BioPlex
JUN
Tchem
Family:  TF
Novelty:  0.00006856
p_int:  0.998279084
p_ni:  0.001688876
p_wrong:  0.00003204
Score:  0.558
Data Source:  BioPlex,STRINGDB
Pathways (19)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Metabolism of proteins
Reactome
PERK regulates gene expression
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Metabolism of proteins
PERK regulates gene expression
Unfolded Protein Response (UPR)
Gene Ontology Terms (23)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
9
40
54
99.1
waist-hip ratio
6
36
42
98.1
BMI-adjusted waist circumference
5
20
23
96.9
waist circumference
2
20
21
95.6
high density lipoprotein cholesterol measurement
5
4
8
93.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
54
99.1
waist-hip ratio
42
98.1
BMI-adjusted waist circumference
23
96.9
waist circumference
21
95.6
high density lipoprotein cholesterol measurement
8
93.6
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
CCAAT/enhancer binding protein gamma
704322
Mouse
MGI:104982
12611
Rat
RGD:2330
25301
Dog
CCAAT enhancer binding protein gamma
VGNC:39089
100686458
Horse
CCAAT enhancer binding protein gamma
VGNC:16382
100630820
Species
Name
OMA
EggNOG
Inparanoid
Macaque
CCAAT/enhancer binding protein gamma
Mouse
Rat
Dog
CCAAT enhancer binding protein gamma
Horse
CCAAT enhancer binding protein gamma
Publication Statistics
PubMed Score 11.60
PubMed score by year
PubTator Score 13.69
PubTator score by year