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Tbio
FOSB
Protein fosB

Protein Summary
Description
FosB interacts with Jun proteins enhancing their DNA binding activity. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353609
  • ENSP00000245919
  • ENSG00000125740
  • ENST00000417353
  • ENSP00000407207
  • ENST00000443841
  • ENSP00000414177
  • ENST00000585836
  • ENSP00000467497
  • ENST00000586615
  • ENSP00000468207
  • ENST00000591858
  • ENSP00000466530
  • ENST00000615753
  • ENSP00000485018

Symbol
  • G0S3
  • AP-1
  • G0S3
  • GOS3
  • GOSB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor
0.87
transcription factor binding site profile
0.87
small molecule perturbation
0.79
biological process
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.89   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 472   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 529.89   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (117)
JUNB
Tbio
Family:  TF
Novelty:  0.00841656
p_int:  0.999998424
p_wrong:  0.000001576
Score:  0.992
Data Source:  BioPlex,STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.997
Data Source:  STRINGDB
JUND
Tbio
Family:  TF
Novelty:  0.00277701
Score:  0.995
Data Source:  Reactome,STRINGDB
FOS
Tbio
Family:  TF
Novelty:  0.00006103
Score:  0.983
Data Source:  STRINGDB
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
Score:  0.953
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.946
Data Source:  STRINGDB
MAFG
Tbio
Family:  TF
Novelty:  0.01605125
Score:  0.941
Data Source:  STRINGDB
EGR1
Tbio
Family:  TF
Novelty:  0.00039994
Score:  0.94
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.937
Data Source:  STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 4 of 4
CALM1
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
CALM3
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
CALM2
Tclin
Family:  Other
KEGG Distance:  3
Common Pathways:  2
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  3
Common Pathways:  2
Pathways (22)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Estrogen-dependent gene expression
Signal Transduction
Signaling by Nuclear Receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
6
91.1
apolipoprotein B measurement
1
3
3
84.3
C-reactive protein measurement
2
3
3
71.8
low density lipoprotein cholesterol measurement
1
2
2
68
platelet count
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
91.1
apolipoprotein B measurement
3
84.3
C-reactive protein measurement
3
71.8
low density lipoprotein cholesterol measurement
2
68
platelet count
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
FosB proto-oncogene, AP-1 transcription factor subunit
715896
Mouse
MGI:95575
14282
Rat
RGD:1308198
100360880
Dog
FosB proto-oncogene, AP-1 transcription factor subunit
VGNC:40941
484445
Horse
FosB proto-oncogene, AP-1 transcription factor subunit
VGNC:18096
100065680
Species
Name
OMA
EggNOG
Inparanoid
Macaque
FosB proto-oncogene, AP-1 transcription factor subunit
Mouse
Rat
Dog
FosB proto-oncogene, AP-1 transcription factor subunit
Horse
FosB proto-oncogene, AP-1 transcription factor subunit
Publication Statistics
PubMed Score 529.89
PubMed score by year
PubTator Score 359.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title