Tbio FOSB Protein fosB

Protein Classes

PANTHER Classes

Protein / ... / Basic Leucine Zipper Transcription Factor / Protein Fosb

Protein Summary

Description

FosB interacts with Jun proteins enhancing their DNA binding activity. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P53539
• A8K9K5
• A8VJE1
• A8VJE6
• A8VJF0
• A8VJF3
• A8VJF7
• A8VJG1
• A8VJG5
• A8VJG9
• E7EPR6
• E9PHJ3
• K7EMJ6
• Q49AD7

Gene Name

• FOSB

Ensembl ID

• ENST00000353609
• ENSP00000245919
• ENSG00000125740
• ENST00000417353
• ENSP00000407207
• ENST00000443841
• ENSP00000414177
• ENST00000585836
• ENSP00000467497
• ENST00000586615
• ENSP00000468207
• ENST00000591858
• ENSP00000466530
• ENST00000615753
• ENSP00000485018

Symbol

• G0S3
• AP-1
• G0S3
• GOS3
• GOSB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
transcription factor	0.87
transcription factor binding site profile	0.87
small molecule perturbation	0.79
biological process	0.78

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 471.04   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 472   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 471.04   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (6)

1 – 5 of 6

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (22)

Reactome (4)

KEGG (5)

PathwayCommons (7)

WikiPathways (6)

ESR-mediated signaling (R-HSA-8939211)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ESR-mediated signaling	189 targets	R-HSA-8939211
Reactome	Estrogen-dependent gene expression	119 targets	R-HSA-9018519
Reactome	Signal Transduction	2704 targets	R-HSA-162582
Reactome	Signaling by Nuclear Receptors	232 targets	R-HSA-9006931

Name	Explore in Pharos	Explore in Source
ESR-mediated signaling	189 targets	R-HSA-8939211
Estrogen-dependent gene expression	119 targets	R-HSA-9018519
Signal Transduction	2704 targets	R-HSA-162582
Signaling by Nuclear Receptors	232 targets	R-HSA-9006931

Gene Ontology Terms (18)

Functions (5)

Components (3)

Processes (10)

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Traceable Author Statement (TAS)	ProtInc
transcription factor binding	Traceable Author Statement (TAS)	ProtInc
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (117)

Explore Interacting Targets

1 – 10 of 117

• See Interactions on String-DB

JUNB

Tbio

Family: TF

Novelty: 0.01119828

p_int: 0.999998424

p_wrong: 0.000001576

Score: 0.992

Data Source: BioPlex,STRINGDB

JUN

Tchem

Family: TF

Novelty: 0.00013623

Score: 0.997

Data Source: STRINGDB

JUND

Tbio

Family: TF

Novelty: 0.00337776

Score: 0.995

Data Source: Reactome,STRINGDB

FOS

Tbio

Family: TF

Novelty: 0.00007002

Score: 0.983

Data Source: STRINGDB

CDK5

Tchem

Family: Kinase

Novelty: 0.00081843

Score: 0.953

Data Source: STRINGDB

EP300

Tchem

Family: Epigenetic

Novelty: 0.00060382

Score: 0.946

Data Source: STRINGDB

MAFG

Tbio

Family: TF

Novelty: 0.01506352

Score: 0.941

Data Source: STRINGDB

EGR1

Tbio

Family: TF

Novelty: 0.0004835

Score: 0.94

Data Source: STRINGDB

MYC

Tbio

Family: TF

Novelty: 0.000073

Score: 0.937

Data Source: STRINGDB

HIST1H2BA

Tbio

Novelty: 0.03503778

Score: 0.934

Data Source: STRINGDB

Publication Statistics

PubMed Score  471.04

PubMed score by year

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PubTator Score  359.43

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWL

1-70

VQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARA

70-140

RPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKER

140-210

LEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASL

210-280

FTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL

280-338

MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL

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Uniprot Keyword

3D-structure
Alternative splicing
Complete proteome
DNA-binding
Nucleus
Polymorphism
Reference proteome