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Tbio
FOSB
Protein fosB

Protein Summary
Description
FosB interacts with Jun proteins enhancing their DNA binding activity. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353609
  • ENSP00000245919
  • ENSG00000125740
  • ENST00000417353
  • ENSP00000407207
  • ENST00000443841
  • ENSP00000414177
  • ENST00000585836
  • ENSP00000467497
  • ENST00000586615
  • ENSP00000468207
  • ENST00000591858
  • ENSP00000466530
  • ENST00000615753
  • ENSP00000485018

Symbol
  • G0S3
  • AP-1
  • G0S3
  • GOS3
  • GOSB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor
0.87
transcription factor binding site profile
0.87
small molecule perturbation
0.79
biological process
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 793.7   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 472   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 793.7   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 472   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0