Protein Classes
Protein Summary
FosB interacts with Jun proteins enhancing their DNA binding activity. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000353609
- ENSP00000245919
- ENSG00000125740
- ENST00000417353
- ENSP00000407207
- ENST00000443841
- ENSP00000414177
- ENST00000585836
- ENSP00000467497
- ENST00000586615
- ENSP00000468207
- ENST00000591858
- ENSP00000466530
- ENST00000615753
- ENSP00000485018
- G0S3
- AP-1
- G0S3
- GOS3
- GOSB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.98 | ||
transcription factor | 0.87 | ||
transcription factor binding site profile | 0.87 | ||
small molecule perturbation | 0.79 | ||
biological process | 0.78 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 471.04 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 472 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 471.04 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 472 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (22)
Reactome (4)
KEGG (5)
PathwayCommons (7)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ESR-mediated signaling | ||||
Reactome | Estrogen-dependent gene expression | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Nuclear Receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ESR-mediated signaling | ||||
Estrogen-dependent gene expression | ||||
Signal Transduction | ||||
Signaling by Nuclear Receptors | ||||
Gene Ontology Terms (18)
Functions (5)
Components (3)
Processes (10)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (117)
1 – 10 of 117
JUNB
Family: TF
Novelty: 0.01119828
p_int: 0.999998424
p_wrong: 0.000001576
Score: 0.992
Data Source: BioPlex,STRINGDB
JUN
Family: TF
Novelty: 0.00013623
Score: 0.997
Data Source: STRINGDB
JUND
Family: TF
Novelty: 0.00337776
Score: 0.995
Data Source: Reactome,STRINGDB
FOS
Family: TF
Novelty: 0.00007002
Score: 0.983
Data Source: STRINGDB
CDK5
Family: Kinase
Novelty: 0.00081843
Score: 0.953
Data Source: STRINGDB
EP300
Family: Epigenetic
Novelty: 0.00060382
Score: 0.946
Data Source: STRINGDB
MAFG
Family: TF
Novelty: 0.01506352
Score: 0.941
Data Source: STRINGDB
EGR1
Family: TF
Novelty: 0.0004835
Score: 0.94
Data Source: STRINGDB
MYC
Family: TF
Novelty: 0.000073
Score: 0.937
Data Source: STRINGDB
HIST1H2BA
Novelty: 0.03503778
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score 471.04
PubMed score by year
PubTator Score 359.43
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWL
1-70
VQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARA
70-140
RPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKER
140-210
LEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASL
210-280
FTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL
280-338
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGTSYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNLTASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPSLLAL
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