Protein Classes
Protein Summary
FosB interacts with Jun proteins enhancing their DNA binding activity. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000353609
- ENSP00000245919
- ENSG00000125740
- ENST00000417353
- ENSP00000407207
- ENST00000443841
- ENSP00000414177
- ENST00000585836
- ENSP00000467497
- ENST00000586615
- ENSP00000468207
- ENST00000591858
- ENSP00000466530
- ENST00000615753
- ENSP00000485018
- G0S3
- AP-1
- G0S3
- GOS3
- GOSB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.98 | ||
transcription factor | 0.87 | ||
transcription factor binding site profile | 0.87 | ||
small molecule perturbation | 0.79 | ||
biological process | 0.78 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 515.12 (req: < 5)
Gene RIFs: 37 (req: <= 3)
Antibodies: 472 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 515.12 (req: >= 5)
Gene RIFs: 37 (req: > 3)
Antibodies: 472 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 2 | 3 | 93.2 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 93.2 | |||||
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | FosB proto-oncogene, AP-1 transcription factor subunit | 715896 | ||||||
Mouse | MGI:95575 | 14282 | ||||||
Rat | RGD:1308198 | 100360880 | ||||||
Dog | FosB proto-oncogene, AP-1 transcription factor subunit | VGNC:40941 | 484445 | |||||
Horse | FosB proto-oncogene, AP-1 transcription factor subunit | VGNC:18096 | 100065680 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | FosB proto-oncogene, AP-1 transcription factor subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | FosB proto-oncogene, AP-1 transcription factor subunit | |||||
Horse | FosB proto-oncogene, AP-1 transcription factor subunit | |||||
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (22)
Reactome (4)
KEGG (5)
PathwayCommons (7)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ESR-mediated signaling | ||||
Reactome | Estrogen-dependent gene expression | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by Nuclear Receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ESR-mediated signaling | ||||
Estrogen-dependent gene expression | ||||
Signal Transduction | ||||
Signaling by Nuclear Receptors | ||||
Gene Ontology Terms (18)
Functions (5)
Components (3)
Processes (10)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (117)
1 – 10 of 117
JUNB
Family: TF
Novelty: 0.00841656
p_int: 0.999998424
p_wrong: 0.000001576
Score: 0.992
Data Source: BioPlex,STRINGDB
JUN
Family: TF
Novelty: 0.00006856
Score: 0.997
Data Source: STRINGDB
JUND
Family: TF
Novelty: 0.00277701
Score: 0.995
Data Source: Reactome,STRINGDB
FOS
Family: TF
Novelty: 0.00006103
Score: 0.983
Data Source: STRINGDB
CDK5
Family: Kinase
Novelty: 0.00071394
Score: 0.953
Data Source: STRINGDB
EP300
Family: Epigenetic
Novelty: 0.00055009
Score: 0.946
Data Source: STRINGDB
MAFG
Family: TF
Novelty: 0.01605125
Score: 0.941
Data Source: STRINGDB
EGR1
Family: TF
Novelty: 0.00039994
Score: 0.94
Data Source: STRINGDB
MYC
Family: TF
Novelty: 0.00005734
Score: 0.937
Data Source: STRINGDB
HIST1H2BA
Novelty: 0.02431803
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score 515.12
PubMed score by year
PubTator Score 359.43
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword