Protein Summary
FosB interacts with Jun proteins enhancing their DNA binding activity. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000353609
- ENSP00000245919
- ENSG00000125740
- ENST00000417353
- ENSP00000407207
- ENST00000443841
- ENSP00000414177
- ENST00000585836
- ENSP00000467497
- ENST00000586615
- ENSP00000468207
- ENST00000591858
- ENSP00000466530
- ENST00000615753
- ENSP00000485018
- G0S3
- AP-1
- G0S3
- GOS3
- GOSB
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.98 | ||
transcription factor | 0.87 | ||
transcription factor binding site profile | 0.87 | ||
small molecule perturbation | 0.79 | ||
biological process | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 793.7 (req: < 5)
Gene RIFs: 52 (req: <= 3)
Antibodies: 472 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 793.7 (req: >= 5)
Gene RIFs: 52 (req: > 3)
Antibodies: 472 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0