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Tclin
ACLY
ATP-citrate synthase

Protein Summary
Description
ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352035
  • ENSP00000253792
  • ENSG00000131473
  • ENST00000353196
  • ENSP00000345398
  • ENST00000393896
  • ENSP00000377474
  • ENST00000537919
  • ENSP00000445349
  • ENST00000590151
  • ENSP00000466259

Symbol
  • ACL
  • ATPCL
  • CLATP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
1
drug perturbation
0.99
molecular function
0.98
disease perturbation
0.97


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 880.25   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 481   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 880.25   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 481   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 19
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (305)
CS
Tbio
Family:  Enzyme
Novelty:  0.00154214
Score:  0.995
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.994
Data Source:  STRINGDB
ACACA
Tchem
Family:  Enzyme
Novelty:  0.00248313
Score:  0.988
Data Source:  STRINGDB
ACACB
Tchem
Family:  Enzyme
Novelty:  0.00462116
Score:  0.981
Data Source:  STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
Score:  0.98
Data Source:  STRINGDB
DLAT
Tbio
Family:  Enzyme
Novelty:  0.00311191
Score:  0.973
Data Source:  STRINGDB
ACO2
Tbio
Family:  Enzyme
Novelty:  0.00276725
Score:  0.968
Data Source:  STRINGDB
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
Score:  0.96
Data Source:  STRINGDB
MDH2
Tchem
Family:  Enzyme
Novelty:  0.00217694
Score:  0.959
Data Source:  STRINGDB
ACO1
Tbio
Family:  Enzyme
Novelty:  0.00194023
Score:  0.958
Data Source:  STRINGDB
Pathways (38)
ChREBP activates metabolic gene expression (R-HSA-163765)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ChREBP activates metabolic gene expression
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
ChREBP activates metabolic gene expression
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
5
7
96.5
reticulocyte measurement
3
3
4
94.7
balding measurement
1
1
1
64.4
eosinophil count
2
1
2
48.5
heel bone mineral density
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
7
96.5
reticulocyte measurement
4
94.7
balding measurement
1
64.4
eosinophil count
2
48.5
heel bone mineral density
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP citrate lyase
VGNC:6326
454672
Macaque
ATP citrate lyase
708501
Mouse
MGI:103251
104112
Rat
RGD:2018
24159
Dog
ATP citrate lyase
VGNC:37511
607852
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP citrate lyase
Macaque
ATP citrate lyase
Mouse
Rat
Dog
ATP citrate lyase
Publication Statistics
PubMed Score 880.25
PubMed score by year
PubTator Score 226.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title