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Tbio
ARFIP2
Arfaptin-2

Protein Summary
Description
Putative target protein of ADP-ribosylation factor. Involved in membrane ruffling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254584
  • ENSP00000254584
  • ENSG00000132254
  • ENST00000396777
  • ENSP00000379998
  • ENST00000423813
  • ENSP00000398375
  • ENST00000445086
  • ENSP00000391427

Symbol
  • POR1
  • POR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
hub protein
0.96
histone modification site profile
0.92
microRNA
0.72
kinase perturbation
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.9   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.9   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor interacting protein 2
VGNC:3213
450994
Macaque
ADP ribosylation factor interacting protein 2
710929
Mouse
MGI:1924182
76932
Rat
RGD:1303204
293344
Dog
ADP ribosylation factor interacting protein 2
VGNC:38039
610132
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADP ribosylation factor interacting protein 2
Macaque
ADP ribosylation factor interacting protein 2
Mouse
Rat
Dog
ADP ribosylation factor interacting protein 2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P53365-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (1063)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Gene Ontology Terms (19)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (60)
1 – 10 of 60
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.999760702
p_ni: 0.000239128
p_wrong: 1.7e-7
Data Source: BioPlex
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.99947853
p_ni: 0.000517162
p_wrong: 0.000004307
Data Source: BioPlex
IFT20
Tbio
Novelty: 0.03005088
p_int: 0.998841636
p_ni: 0.001156084
p_wrong: 0.00000228
Data Source: BioPlex
TMEM31
Tdark
Novelty: 0.65381391
p_int: 0.991600033
p_ni: 0.001738034
p_wrong: 0.006661933
Data Source: BioPlex
DUSP22
Tbio
Family: Enzyme
Novelty: 0.01579003
p_int: 0.967102726
p_ni: 0.00646234
p_wrong: 0.026434934
Score: 0.159
Data Source: BioPlex,STRINGDB
ARFIP1
Tbio
Novelty: 0.20178246
p_int: 0.951297303
p_ni: 0.048702697
Score: 0.435
Data Source: BioPlex,STRINGDB
ARL1
Tbio
Family: Enzyme
Novelty: 0.29930049
Score: 0.998
Data Source: Reactome,STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.995
Data Source: STRINGDB
ARF1
Tchem
Family: Enzyme
Novelty: 0.00208554
Score: 0.975
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  77.90

PubMed score by year
PubTator Score  121.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer