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Tchem
PLK1
Serine/threonine-protein kinase PLK1

Protein Summary
Description
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300093
  • ENSP00000300093
  • ENSG00000166851

Symbol
  • PLK
  • PLK
  • STPK13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
1
molecular function
0.99
kinase perturbation
0.98
cellular component
0.95


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1763.87   (req: < 5)
Gene RIFs: 498   (req: <= 3)
Antibodies: 1067   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1763.87   (req: >= 5)
Gene RIFs: 498   (req: > 3)
Antibodies: 1067   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 176
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
18.8
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polo like kinase 1
VGNC:8992
453991
Macaque
polo like kinase 1
697686
Mouse
MGI:97621
18817
Rat
RGD:3352
25515
Dog
polo like kinase 1
VGNC:44695
489971
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polo like kinase 1
Macaque
polo like kinase 1
Mouse
Rat
Dog
polo like kinase 1
Protein Structure (61 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P53350-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 61
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (292)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome
AURKA Activation by TPX2
Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome
Activation of NIMA Kinases NEK9, NEK6, NEK7
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
AURKA Activation by TPX2
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Activation of NIMA Kinases NEK9, NEK6, NEK7
Gene Ontology Terms (66)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (798)
1 – 10 of 798
ERCC6L
Tbio
Novelty: 0.01959203
p_int: 0.999999981
p_ni: 1.9e-8
Score: 0.998
Data Source: BioPlex,STRINGDB
PPP6R2
Tbio
Family: Enzyme
Novelty: 0.12886225
p_int: 0.999999874
p_ni: 1.26e-7
Score: 0.18
Data Source: BioPlex,STRINGDB
TOPBP1
Tbio
Family: Enzyme
Novelty: 0.00735579
p_int: 0.999995869
p_ni: 0.000004115
p_wrong: 1.6e-8
Score: 0.724
Data Source: BioPlex,STRINGDB
TMF1
Tbio
Novelty: 0.02543575
p_int: 0.999992869
p_ni: 0.000004146
p_wrong: 0.000002985
Score: 0.179
Data Source: BioPlex,STRINGDB
ZC3HC1
Tbio
Novelty: 0.089692
p_int: 0.999990334
p_ni: 0.000009666
Score: 0.175
Data Source: BioPlex,STRINGDB
RAI14
Tbio
Novelty: 0.06291577
p_int: 0.999958487
p_ni: 0.000041512
Score: 0.323
Data Source: BioPlex,STRINGDB
C1orf226
Tdark
Novelty: 3.45031712
p_int: 0.99993952
p_ni: 0.000060477
p_wrong: 3e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
BORA
Tbio
Novelty: 0.0374925
p_int: 0.999884819
p_ni: 0.000115181
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
MPRIP
Tbio
Family: Enzyme
Novelty: 0.03253403
p_int: 0.999794301
p_ni: 0.000205699
Data Source: BioPlex
ARHGAP5
Tbio
Family: Enzyme
Novelty: 0.03683127
p_int: 0.998995359
p_ni: 0.001004641
Score: 0.196
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1763.87

PubMed score by year
PubTator Score  1077.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer