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Tbio
PPP5C
Serine/threonine-protein phosphatase 5

Protein Summary
Description
Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000012443
  • ENSP00000012443
  • ENSG00000011485

Symbol
  • PPP5
  • PP5
  • PPT
  • PPP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
interacting protein
0.92
transcription factor perturbation
0.88
transcription factor binding site profile
0.75
molecular function
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.45   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 558   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.45   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 558   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
2
0
1.1
97.8
hemoglobin measurement
2
1
2
54.8
triglyceride measurement
1
1
1
38.5
eosinophil count
1
1
1
18.8
basophil percentage of leukocytes
1
1
1
18.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
97.8
hemoglobin measurement
2
54.8
triglyceride measurement
1
38.5
eosinophil count
1
18.8
basophil percentage of leukocytes
1
18.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 5 catalytic subunit
VGNC:7566
456150
Macaque
protein phosphatase 5 catalytic subunit
716214
Mouse
MGI:102666
19060
Rat
RGD:68415
65179
Dog
protein phosphatase 5 catalytic subunit
VGNC:49945
612199
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 5 catalytic subunit
Macaque
protein phosphatase 5 catalytic subunit
Mouse
Rat
Dog
protein phosphatase 5 catalytic subunit
Protein Data Bank (18)
1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (34)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
ESR-mediated signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
ESR-mediated signaling
Gene Ontology Terms (39)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (155)
1 – 10 of 155
POLD2
Tbio
Family: Enzyme
Novelty: 0.05932998
p_int: 0.960531824
p_ni: 0.039468172
p_wrong: 4e-9
Score: 0.238
Data Source: BioPlex,STRINGDB
RAB41
Tdark
Family: Enzyme
p_int: 0.950270687
p_ni: 0.049729313
Score: 0.633
Data Source: BioPlex,STRINGDB
BPHL
Tbio
Family: Enzyme
Novelty: 0.03437536
p_int: 0.911727909
p_ni: 0.088272091
Score: 0.472
Data Source: BioPlex,STRINGDB
GADL1
Tbio
Family: Enzyme
Novelty: 0.018813
p_int: 0.850368967
p_ni: 0.149631033
Data Source: BioPlex
HSP90AA1
Tchem
Novelty: 0.00016774
Score: 0.988
Data Source: STRINGDB
CDC37
Tbio
Novelty: 0.03730196
Score: 0.977
Data Source: STRINGDB
HSP90AB1
Tchem
Novelty: 0.00907961
Score: 0.976
Data Source: STRINGDB
PTGES3
Tbio
Family: Enzyme
Novelty: 0.0082783
Score: 0.976
Data Source: STRINGDB
PPID
Tchem
Family: Enzyme
Novelty: 0.01068886
Score: 0.948
Data Source: STRINGDB
STIP1
Tbio
Novelty: 0.00590952
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.45

PubMed score by year
PubTator Score  120.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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