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Tbio
SLC25A1
Tricarboxylate transport protein, mitochondrial

Protein Summary
Description
Involved in citrate-H(+)/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215882
  • ENSP00000215882
  • ENSG00000100075

Symbol
  • SLC20A3
  • CTP
  • SEA
  • CMS23
  • D2L2AD
  • SLC20A3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.88
transcription factor perturbation
0.8
cellular component
0.78
PubMedID
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.67   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.67   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (95)
ACLY
Tclin
Family:  Enzyme
Novelty:  0.00114812
Score:  0.829
Data Source:  STRINGDB
PCYT2
Tbio
Family:  Enzyme
Novelty:  0.03267621
Score:  0.758
Data Source:  STRINGDB
ESS2
Tbio
Novelty:  0.00163665
Score:  0.754
Data Source:  STRINGDB
CLTCL1
Tbio
Novelty:  0.05667807
Score:  0.705
Data Source:  STRINGDB
CLTC
Tbio
Novelty:  0.00256674
Score:  0.703
Data Source:  STRINGDB
CTPS1
Tbio
Family:  Enzyme
Novelty:  0.00911596
Score:  0.675
Data Source:  STRINGDB
DGCR2
Tbio
Novelty:  0.05838132
Score:  0.656
Data Source:  STRINGDB
SEPT8
Tbio
Novelty:  0.01431499
Score:  0.653
Data Source:  STRINGDB
TBX1
Tbio
Family:  TF
Novelty:  0.00154882
Score:  0.648
Data Source:  STRINGDB
FASN
Tchem
Family:  Enzyme
Novelty:  0.00142172
Score:  0.647
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Gluconeogenesis
Reactome
Glucose metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Gluconeogenesis
Glucose metabolism
Metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
36.5
amino acid measurement
1
1
1
36.5
protein measurement
1
1
1
36.5
metabolite measurement
1
1
1
21.2
serum metabolite measurement
1
1
1
9.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
36.5
amino acid measurement
1
36.5
protein measurement
1
36.5
metabolite measurement
1
21.2
serum metabolite measurement
1
9.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 1
VGNC:7801
458647
Macaque
solute carrier family 25 member 1
719075
Mouse
MGI:1345283
13358
Rat
RGD:3703
29743
Dog
solute carrier family 25 member 1
VGNC:46290
608348
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 1
Macaque
solute carrier family 25 member 1
Mouse
Rat
Dog
solute carrier family 25 member 1
Publication Statistics
PubMed Score 189.67
PubMed score by year
PubTator Score 88.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title