BLVRA
Biliverdin reductase A
Protein Summary
Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IX alpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH. Mutations in this gene are associated with hyperbiliverdinemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2011]
- ENST00000265523
- ENSP00000265523
- ENSG00000106605
- ENST00000402924
- ENSP00000385757
- BLVR
- BVR
- BVR
- BLVR
- BVRA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
virus perturbation | 0.9 | ||
kinase perturbation | 0.88 | ||
disease perturbation | 0.87 | ||
histone modification site profile | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 293.9 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 288 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 293.9 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 288 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0