Tbio ART1 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

Protein Summary

Description

Has ADP-ribosyltransferase activity toward GLP1R. ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P52961
• Q6NTD2
• Q96KT9

Gene Name

• ART1

Ensembl ID

• ENST00000250693
• ENSP00000250693
• ENSG00000129744

Symbol

• RT6
• ART2
• ARTC1
• CD296

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.74
disease perturbation	0.74
cellular component	0.7
cell line	0.6
small molecule perturbation	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.25   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.25   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0