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Tbio
LBX1
Transcription factor LBX1

Protein Summary
Description
Transcription factor required for the development of GABAergic interneurons in the dorsal horn of the spinal cord and migration and further development of hypaxial muscle precursor cells for limb muscles, diaphragm and hypoglossal cord. This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370193
  • ENSP00000359212
  • ENSG00000138136

Symbol
  • LBX1H
  • HPX6
  • HPX-6
  • LBX1H
  • homeobox
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
biological process
0.68
protein domain
0.58
PubMedID
0.57
transcription factor binding site profile
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.57   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.57   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
6
2
0
1.5
88.5
mean corpuscular volume
1
1
1
44.2
1
1
0
1.6
26
1
1
1
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
0
1.5
88.5
mean corpuscular volume
1
44.2
0
1.6
26
1
4.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ladybird homeobox 1
VGNC:4725
466187
Mouse
MGI:104867
16814
Rat
RGD:1564197
499362
Dog
ladybird homeobox 1
VGNC:42603
486850
Horse
ladybird homeobox 1
VGNC:19602
100070213
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ladybird homeobox 1
Mouse
Rat
Dog
ladybird homeobox 1
Horse
ladybird homeobox 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P52954-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (69)
1 – 10 of 69
SKOR1
Tbio
Novelty:  0.07579796
Score:  0.931
Data Source:  STRINGDB
LHX5
Tbio
Family:  TF
Novelty:  0.04947314
Score:  0.785
Data Source:  STRINGDB
DPRX
Tdark
Family:  TF
Novelty:  0.15983197
Score:  0.78
Data Source:  STRINGDB
TPRXL
Tdark
Novelty:  2.10371636
Score:  0.72
Data Source:  STRINGDB
TPRX1
Tdark
Novelty:  0.4834652
Score:  0.718
Data Source:  STRINGDB
FBXW4
Tbio
Novelty:  0.06255177
Score:  0.711
Data Source:  STRINGDB
DPCD
Tbio
Novelty:  0.09869683
Score:  0.711
Data Source:  STRINGDB
ARGFX
Tdark
Family:  TF
Novelty:  0.84035526
Score:  0.674
Data Source:  STRINGDB
GPR153
Tdark
Family:  GPCR
Novelty:  0.44419008
Score:  0.674
Data Source:  STRINGDB
LHX1
Tbio
Family:  TF
Novelty:  0.01291002
Score:  0.658
Data Source:  STRINGDB
Publication Statistics
PubMed Score  181.57

PubMed score by year
PubTator Score  24.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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