Tbio NKX2-5 Homeobox protein Nkx-2.5

Protein Summary

Description

Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter (PubMed:22849347, PubMed:26926761). It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development. This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P52952
• A8K3K0
• B4DNB6
• E9PBU6

Gene Name

• NKX2-5

Ensembl ID

• ENST00000329198
• ENSP00000327758
• ENSG00000183072
• ENST00000424406
• ENSP00000395378
• ENST00000521848
• ENSP00000427906

Symbol

• CSX
• NKX2.5
• NKX2E
• CSX
• CSX1
• VSD3
• CHNG5
• HLHS2
• NKX2E
• NKX2.5
• NKX4-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.99
phenotype	0.75
cell type or tissue	0.65
PubMedID	0.63

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Nkx-2.5

Protein / Nucleic Acid Binding / Dna Binding Protein / Homeobox Protein Nkx-2.5

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Nkx-2.5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1032.11   (req: < 5)

Gene RIFs: 164   (req: <= 3)

Antibodies: 468   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1032.11   (req: >= 5)

Gene RIFs: 164   (req: > 3)

Antibodies: 468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0