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Tbio
CAPZA1
F-actin-capping protein subunit alpha-1

Protein Summary
Description
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263168
  • ENSP00000263168
  • ENSG00000116489

Symbol
  • CAPZ
  • CAZ1
  • CAPPA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
1
kinase perturbation
0.95
histone modification site profile
0.89
interacting protein
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.79   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.79   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
82.5
intraocular pressure measurement
2
3
3
78.7
body height
1
1
1
59.7
mean platelet volume
1
1
1
49.4
monocyte count
1
1
1
45.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
82.5
intraocular pressure measurement
3
78.7
body height
1
59.7
mean platelet volume
1
49.4
monocyte count
1
45.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
capping actin protein of muscle Z-line subunit alpha 1
VGNC:11303
457101
Macaque
capping actin protein of muscle Z-line alpha subunit 1
705653
Mouse
MGI:106227
12340
Rat
RGD:1587438
691149
Dog
capping actin protein of muscle Z-line alpha subunit 1
475857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
capping actin protein of muscle Z-line subunit alpha 1
Macaque
capping actin protein of muscle Z-line alpha subunit 1
Mouse
Rat
Dog
capping actin protein of muscle Z-line alpha subunit 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52907-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Advanced glycosylation endproduct receptor signaling
Asparagine N-linked glycosylation
COPI-independent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
Gene Ontology Terms (20)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (269)
1 – 10 of 269
RCSD1
Tbio
Novelty: 0.11360488
p_int: 0.998908883
p_ni: 0.001091117
Score: 0.959
Data Source: BioPlex,STRINGDB
SH3KBP1
Tbio
Family: Enzyme
Novelty: 0.01454593
p_int: 0.998810611
p_ni: 0.001189389
Score: 0.665
Data Source: BioPlex,STRINGDB
PLEKHO2
Tdark
Novelty: 0.48296621
p_int: 0.998651971
p_ni: 0.001348029
Score: 0.847
Data Source: BioPlex,STRINGDB
PLEKHO1
Tbio
Novelty: 0.01658553
p_int: 0.990114244
p_ni: 0.009885756
Score: 0.579
Data Source: BioPlex,STRINGDB
DCTN5
Tdark
Novelty: 0.19530162
p_int: 0.988264222
p_ni: 0.011735778
Score: 0.974
Data Source: BioPlex,Reactome,STRINGDB
CAPZA2
Tbio
Novelty: 0.14014918
p_int: 0.977832576
p_ni: 0.022167424
Score: 0.973
Data Source: BioPlex,STRINGDB
CAPZB
Tbio
Novelty: 0.03509224
Score: 0.999
Data Source: Reactome,STRINGDB
DCTN2
Tbio
Novelty: 0.01045432
Score: 0.983
Data Source: Reactome,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.982
Data Source: STRINGDB
ACTR1A
Tbio
Novelty: 0.06306209
Score: 0.98
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  30.79

PubMed score by year
PubTator Score  13.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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