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Tchem
AKR1C2
Aldo-keto reductase family 1 member C2

Protein Summary
Description
Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380753
  • ENSP00000370129
  • ENSG00000151632
  • ENST00000455190
  • ENSP00000408440

Symbol
  • DDH2
  • DD
  • DD2
  • TDD
  • BABP
  • DD-2
  • DDH2
  • HBAB
  • HAKRD
  • MCDR2
  • SRXY8
  • DD/BABP
  • AKR1C-pseudo
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.94
molecular function
0.91
chemical
0.9
biological process
0.71
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 796.17   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 796.17   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Active Ligands (49)
1 – 10 of 49
CHEMBL2323522
Rendered image for CHEMBL2323522
CHEMBL4081954
Rendered image for CHEMBL4081954
CHEMBL4089817
Rendered image for CHEMBL4089817
CHEMBL2323507
Rendered image for CHEMBL2323507
CHEMBL2323511
Rendered image for CHEMBL2323511
N-Phenylanthranilic acid
Rendered image for N-Phenylanthranilic acid
CHEMBL2323508
Rendered image for CHEMBL2323508
CHEMBL2323472
Rendered image for CHEMBL2323472
CHEMBL2323490
Rendered image for CHEMBL2323490
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
3
4
95.6
waist-hip ratio
3
8
9
90.1
BMI-adjusted waist-hip ratio
3
6
7
86.1
hip circumference
1
5
5
73
BMI-adjusted waist circumference
1
2
2
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
95.6
waist-hip ratio
9
90.1
BMI-adjusted waist-hip ratio
7
86.1
hip circumference
5
73
BMI-adjusted waist circumference
2
63.6
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Cow
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
282138
Species
Name
OMA
EggNOG
Inparanoid
Cow
aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52895-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Reactome
Synthesis of bile acids and bile salts
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Metabolism
Metabolism of lipids
Metabolism of steroids
Synthesis of bile acids and bile salts
Gene Ontology Terms (24)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (64)
1 – 10 of 64
AKR1C1
Tchem
Family:  Enzyme
Novelty:  0.0043847
p_int:  1
Score:  0.991
Data Source:  BioPlex,STRINGDB
AKR1C4
Tchem
Family:  Enzyme
Novelty:  0.00925635
p_int:  0.999999875
p_ni:  1.25e-7
Score:  0.867
Data Source:  BioPlex,STRINGDB
ZFP1
Tbio
Family:  TF
Novelty:  0.02526416
p_int:  0.999999654
p_ni:  3.44e-7
p_wrong:  2e-9
Score:  0.329
Data Source:  BioPlex,STRINGDB
AKR1C3
Tchem
Family:  Enzyme
Novelty:  0.00257785
p_int:  0.999999608
p_ni:  3.91e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
IPO8
Tbio
Novelty:  0.00934966
p_int:  0.789381292
p_ni:  0.210618708
Score:  0.222
Data Source:  BioPlex,STRINGDB
SRD5A1
Tclin
Family:  Enzyme
Novelty:  0.00987219
Score:  0.965
Data Source:  STRINGDB
SRD5A2
Tclin
Family:  Enzyme
Novelty:  0.00281044
Score:  0.959
Data Source:  STRINGDB
SRD5A3
Tbio
Family:  Enzyme
Novelty:  0.02896703
Score:  0.936
Data Source:  STRINGDB
DHDH
Tbio
Family:  Enzyme
Novelty:  0.00284827
Score:  0.924
Data Source:  STRINGDB
CYP2A6
Tchem
Novelty:  0.00105285
Score:  0.912
Data Source:  STRINGDB
Publication Statistics
PubMed Score  796.17

PubMed score by year
PubTator Score  277.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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