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Tbio
THOP1
Thimet oligopeptidase

Protein Summary
Description
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307741
  • ENSP00000304467
  • ENSG00000172009
  • ENST00000395212
  • ENSP00000378638

Symbol
  • TOP
  • MP78
  • EP24.15
  • MEPD_HUMAN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
kinase perturbation
0.66
tissue sample
0.64
tissue
0.62
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.81   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.81   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
99.6
testosterone measurement
3
3
3
97.8
low density lipoprotein cholesterol measurement
3
3
3
87.4
total cholesterol measurement
1
1
1
43.7
platelet crit
1
1
1
32.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
99.6
testosterone measurement
3
97.8
low density lipoprotein cholesterol measurement
3
87.4
total cholesterol measurement
1
43.7
platelet crit
1
32.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
thimet oligopeptidase 1
721578
Mouse
MGI:1354165
50492
Rat
RGD:68330
64517
Dog
thimet oligopeptidase 1
VGNC:47353
476748
Horse
thimet oligopeptidase 1
VGNC:24088
100059667
Species
Name
OMA
EggNOG
Inparanoid
Macaque
thimet oligopeptidase 1
Mouse
Rat
Dog
thimet oligopeptidase 1
Horse
thimet oligopeptidase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P52888-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (74)
1 – 10 of 74
PAPLN
Tbio
Novelty: 0.06871524
p_int: 0.921857296
p_ni: 0.078142704
Score: 0.54
Data Source: BioPlex,STRINGDB
PREP
Tchem
Family: Enzyme
Novelty: 0.00148266
Score: 0.716
Data Source: STRINGDB
UBE2H
Tbio
Novelty: 0.03259425
Score: 0.713
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.71
Data Source: STRINGDB
IDE
Tchem
Family: Enzyme
Novelty: 0.00207793
Score: 0.699
Data Source: STRINGDB
GNRH1
Tbio
Novelty: 0.00020807
Score: 0.696
Data Source: STRINGDB
PSMF1
Tbio
Novelty: 0.0364376
Score: 0.675
Data Source: STRINGDB
ACE
Tclin
Family: Enzyme
Novelty: 0.00001993
Score: 0.665
Data Source: STRINGDB
CHD6
Tbio
Family: Epigenetic
Novelty: 0.06191686
Score: 0.664
Data Source: STRINGDB
MME
Tclin
Family: Enzyme
Novelty: 0.00019144
Score: 0.658
Data Source: STRINGDB
Publication Statistics
PubMed Score  149.81

PubMed score by year
PubTator Score  63.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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