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Tbio
NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

Protein Summary
Description
Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). This gene encodes a member of the N-deacetylase/N-sulfotransferase subfamily of the sulfotransferase 1 proteins. The encoded enzyme has dual functions in processing glucosamine and heparin polymers, including N-deacetylation and N-sulfation. The encoded protein may be localized to the Golgi. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299641
  • ENSP00000299641
  • ENSG00000166507
  • ENST00000309979
  • ENSP00000310657

Symbol
  • HSST2
  • NST2
  • HSST2
  • N-HSST 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.83
kinase perturbation
0.76
tissue sample
0.69
cell line
0.67
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.84   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.84   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
1
2
2
76.4
C-reactive protein measurement
2
2
2
68.5
FEV/FEC ratio
1
2
2
63.6
1
1
0
1.1
61.4
1
1
0
1.1
56.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
forced expiratory volume
2
76.4
C-reactive protein measurement
2
68.5
FEV/FEC ratio
2
63.6
0
1.1
61.4
0
1.1
56.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-deacetylase and N-sulfotransferase 2
VGNC:51982
738171
Macaque
N-deacetylase and N-sulfotransferase 2
714578
Mouse
MGI:97040
17423
Rat
RGD:1304700
114002
Dog
N-deacetylase and N-sulfotransferase 2
VGNC:51905
100856320
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-deacetylase and N-sulfotransferase 2
Macaque
N-deacetylase and N-sulfotransferase 2
Mouse
Rat
Dog
N-deacetylase and N-sulfotransferase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P52849-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
HS-GAG biosynthesis
Reactome
Heparan sulfate/heparin (HS-GAG) metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
HS-GAG biosynthesis
Heparan sulfate/heparin (HS-GAG) metabolism
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (71)
1 – 10 of 71
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.999663376
p_ni:  0.000336624
Data Source:  BioPlex
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.991025604
p_ni:  0.008974382
p_wrong:  1.4e-8
Data Source:  BioPlex
SDF4
Tbio
Novelty:  0.00105893
p_int:  0.958431361
p_ni:  0.041568638
Score:  0.163
Data Source:  BioPlex,STRINGDB
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.952780116
p_ni:  0.047218556
p_wrong:  0.000001328
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.949198958
p_ni:  0.050801039
p_wrong:  4e-9
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.947873697
p_ni:  0.052126024
p_wrong:  2.79e-7
Data Source:  BioPlex
SIAE
Tbio
Family:  Enzyme
Novelty:  0.01138067
p_int:  0.942970771
p_ni:  0.057028608
p_wrong:  6.21e-7
Data Source:  BioPlex
CRP
Tbio
Novelty:  0.00001517
p_int:  0.919537692
p_ni:  0.080460262
p_wrong:  0.000002046
Data Source:  BioPlex
IFNA21
Tbio
Novelty:  0.00581034
p_int:  0.891178106
p_ni:  0.108821882
p_wrong:  1.2e-8
Data Source:  BioPlex
ST8SIA4
Tbio
Family:  Enzyme
Novelty:  0.00338436
p_int:  0.87859304
p_ni:  0.12140696
Data Source:  BioPlex
Publication Statistics
PubMed Score  26.84

PubMed score by year
PubTator Score  11.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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